An integrated mathematical model of the cardiovascular and respiratory systems

Summary This study presents a lumped model for the human cardiorespiratory system. Specifically, we incorporate a sophisticated gas dissociation and transport system to a fully integrated cardiovascular and pulmonary model. The model provides physiologically consistent predictions in terms of hemody...

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Bibliographic Details
Published in:International journal for numerical methods in biomedical engineering 2016-01, Vol.32 (1), p.e02736-n/a
Main Authors: Trenhago, Paulo Roberto, Fernandes, Luciano Gonçalves, Müller, Lucas Omar, Blanco, Pablo Javier, Feijóo, Raúl Antonino
Format: Article
Language:English
Subjects:
Blood Flow Velocity - physiology
blood gas transport
Blood Pressure - physiology
cardiorespiratory system
Computer Simulation
exercise
Exercise - physiology
gas dissociation
Heart - physiology
Humans
Hydrogen-Ion Concentration
Models, Biological
Pulmonary Gas Exchange - physiology
Systems Integration
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Summary:Summary This study presents a lumped model for the human cardiorespiratory system. Specifically, we incorporate a sophisticated gas dissociation and transport system to a fully integrated cardiovascular and pulmonary model. The model provides physiologically consistent predictions in terms of hemodynamic variables such as pressure, flow rate, gas partial pressures, and pH. We perform numerical simulations to evaluate the behavior of the partial pressures of oxygen and carbon dioxide in different vascular and pulmonary compartments. For this, we design the rest condition with low oxygen requirements and carbon dioxide production and exercise conditions with high oxygen demand and carbon dioxide production. Furthermore, model sensitivity to more relevant model parameters is studied. Copyright © 2015 John Wiley & Sons, Ltd. This study presents a sophisticated gas dissociation and transport system coupled to a fully integrated cardiovascular and pulmonary model. Results yield physiologically consistent predictions in terms of hemodynamic variables such as pressure, flow rate, gas partial pressures, and pH in conditions of rest and exercise.
ISSN:2040-7939
2040-7947
DOI:10.1002/cnm.2736