Visualization of Lymph/Blood Flow in Laparoscopic Colorectal Cancer Surgery by ICG Fluorescence Imaging (Lap-IGFI)

• Published in: Annals of surgical oncology 2016-02, Vol.23 (Suppl 2), p.266-274
• Main Authors: Nishigori, Naoto, Koyama, Fumikazu, Nakagawa, Tadashi, Nakamura, Shinji, Ueda, Takeshi, Inoue, Takashi, Kawasaki, Keijirou, Obara, Shinsaku, Nakamoto, Takayuki, Fujii, Hisao, Nakajima, Yoshiyuki
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Colorectal Cancer; Colorectal Neoplasms - blood supply; Colorectal Neoplasms - pathology; Colorectal Neoplasms - surgery; Coloring Agents; Female; Fluorescence; Follow-Up Studies; Humans; Indocyanine Green; Laparoscopy; Lymph Node Excision; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Staging; Oncology; Optical Imaging - methods; Prognosis; Prospective Studies; Sentinel Lymph Node Biopsy; Surgery; Surgical Oncology
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-015-4509-0

Purpose In laparoscopic colorectal cancer (Lap-CRC) surgery, determination of a suitable mesentery division line and the appropriate degree of lymphadenectomy by tracing the blood supply is critical. We performed visualization of the lymph and blood flow by laparoscopic indocyanine green (ICG) fluorescence imaging (Lap-IGFI). Methods ICG is injected into the submucosa near the tumor via colonoscopy, and the lymph flow is observed. Intestinal blood flow is evaluated by administering ICG intravenously. Results For lymph flow, visualization of the main lymph node basin helped to determine the surgical division line for cases in which the blood flow was not completely visualized. Lap-IGFI changed the surgical plan of the lymphadenectomy in 23.5 %. In our experience, the metastatic rate of ICG-positive nodes was 10.0 %, and the metastatic rate of ICG-negative nodes was 5.3 %. Furthermore, there were no metastatic nodes that were ICG negative more than 5 cm from the tumor. For blood flow, the blood flow distribution of the intestinal wall from the last branch of the vasa recta of the anastomotic site was clearly visualized and proved useful in choosing the extent of intestinal resection. Lap-IGFI changed the surgical plan of the extensive intestinal resection in 16.7 %. Conclusions Lap-IGFI can noninvasively provide detailed lymph and blood flow information and is a useful device to aid in the accurate identification of individual patients’ lymph drainage. This helps dictate adequate lymphadenectomy and the extent of intestinal resection in Lap-CRC surgery.