Rh(III)-Catalyzed [4 + 2] Annulation of Indoles with Diazo Compounds: Access to Pyrimido[1,6‑a]indole-1(2H)‑ones

The Rh­(III)-catalyzed regioselective C2–H bond carbenoid insertion/cyclization of N-amidoindoles with α-acyl diazo compounds has been developed. This method provides a novel approach to 2H-pyrimido­[1,6-a]­indol-1-ones with a broad range of functional group tolerance. The synthetic utilities of the...

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Bibliographic Details
Published in:Organic letters 2016-01, Vol.18 (2), p.192-195
Main Authors: Chen, Xun, Hu, Xinwei, Bai, Siyi, Deng, Yuanfu, Jiang, Huanfeng, Zeng, Wei
Format: Article
Language:English
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Summary:The Rh­(III)-catalyzed regioselective C2–H bond carbenoid insertion/cyclization of N-amidoindoles with α-acyl diazo compounds has been developed. This method provides a novel approach to 2H-pyrimido­[1,6-a]­indol-1-ones with a broad range of functional group tolerance. The synthetic utilities of the approach are demonstrated by versatile chemical transformations.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b03231