Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau

The interneuronal propagation of aggregated tau is believed to play an important role in the pathogenesis of human tauopathies. It requires the uptake of seed-competent tau into cells, seeding of soluble tau in recipient neurons and release of seeded tau into the extracellular space to complete the...

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Bibliographic Details

Published in:	The Journal of neuroscience 2016-01, Vol.36 (3), p.762-772
Main Authors:	Jackson, Samuel J., Kerridge, Caroline, Cooper, Jane, Cavallini, Annalisa, Falcon, Benjamin, Cella, Claire V., Landi, Alessia, Szekeres, Philip G., Murray, Tracey K., Ahmed, Zeshan, Goedert, Michel, Hutton, Michael, O'Neill, Michael J., Bose, Suchira
Format:	Article
Language:	English
Subjects:	Amyloid - genetics Animals Brain - pathology Female HEK293 Cells Humans Mice Mice, Inbred C57BL Mice, Transgenic Neurofibrillary Tangles - genetics Neurofibrillary Tangles - pathology tau Proteins - genetics Tauopathies - genetics Tauopathies - pathology
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