Common swine models of cardiovascular disease for research and training

Cardiovascular diseases are a major health concern and therefore an important topic in biomedical research. Large animal models allow researchers to assess the safety and efficacy of new cardiovascular procedures in systems that resemble human anatomy; additionally, they can be used to emulate scena...

Full description

Saved in:
Bibliographic Details
Published in:Lab animal 2016-02, Vol.45 (2), p.67-74
Main Authors: Crisóstomo, Verónica, Sun, Fei, Maynar, Manuel, Báez-Díaz, Claudia, Blanco, Virginia, Garcia-Lindo, Monica, Usón-Gargallo, Jesús, Sánchez-Margallo, Francisco Miguel
Format: Article
Language:English
Subjects:
Animal Models
Animals
Biomedical and Life Sciences
Biomedical Research - education
Cardiovascular diseases
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - etiology
Cardiovascular Diseases - therapy
Care and treatment
Disease Models, Animal
Life Sciences
Medical personnel
Medical research
Medicine, Experimental
Practice
resource
Sus scrofa
Veterinary Medicine/Veterinary Science
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiovascular diseases are a major health concern and therefore an important topic in biomedical research. Large animal models allow researchers to assess the safety and efficacy of new cardiovascular procedures in systems that resemble human anatomy; additionally, they can be used to emulate scenarios for training purposes. Among the many biomedical models that are described in published literature, it is important that researchers understand and select those that are best suited to achieve the aims of their research, that facilitate the humane care and management of their research animals and that best promote the high ethical standards required of animal research. In this resource the authors describe some common swine models that can be easily incorporated into regular practices of research and training at biomedical institutions. These models use both native and altered vascular anatomy of swine to carry out research protocols, such as testing biological reactions to implanted materials, surgically creating aneurysms using autologous tissue and inducing myocardial infarction through closed-chest procedures. Such models can also be used for training, where native and altered vascular anatomy allow medical professionals to learn and practice challenging techniques in anatomy that closely simulates human systems.
ISSN:0093-7355
1548-4475
DOI:10.1038/laban.935