Enhanced Delivery of Chemotherapy to Tumors Using a Multicomponent Nanochain with Radio-Frequency-Tunable Drug Release

While nanoparticles maximize the amount of chemotherapeutic drug in tumors relative to normal tissues, nanoparticle-based drugs are not accessible to the majority of cancer cells because nanoparticles display patchy, near-perivascular accumulation in tumors. To overcome the limitations of current dr...

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Bibliographic Details
Published in:ACS nano 2012-05, Vol.6 (5), p.4157-4168
Main Authors: Peiris, Pubudu M, Bauer, Lisa, Toy, Randall, Tran, Emily, Pansky, Jenna, Doolittle, Elizabeth, Schmidt, Erik, Hayden, Elliott, Mayer, Aaron, Keri, Ruth A, Griswold, Mark A, Karathanasis, Efstathios
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Cancer
Chains
Disease Models, Animal
Drug delivery systems
Drugs
Humans
Liposomes
Nanoparticles
Nanostructure
Nanotechnology
Neoplasms - drug therapy
Radio Waves
Rats
Transducers
Tumors
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Summary:While nanoparticles maximize the amount of chemotherapeutic drug in tumors relative to normal tissues, nanoparticle-based drugs are not accessible to the majority of cancer cells because nanoparticles display patchy, near-perivascular accumulation in tumors. To overcome the limitations of current drugs in their molecular or nanoparticle form, we developed a nanoparticle based on multicomponent nanochains to deliver drug to the majority of cancer cells throughout a tumor while reducing off-target delivery. The nanoparticle is composed of three magnetic nanospheres and one doxorubicin-loaded liposome assembled in a 100 nm long chain. These nanoparticles display prolonged blood circulation and significant intratumoral deposition in tumor models in rodents. Furthermore, the magnetic particles of the chains serve as a mechanical transducer to transfer radio frequency energy to the drug-loaded liposome. The defects on the liposomal walls trigger the release of free drug capable of spreading throughout the entire tumor, which results in a widespread anticancer effect.
ISSN:1936-0851
1936-086X
DOI:10.1021/nn300652p