Identification of quantitative trait loci for canine hip dysplasia by two sequential multipoint linkage analyses

Canine hip dysplasia (CHD) is characterized by hip laxity and subluxation that can lead to hip osteoarthritis. Studies have shown the involvement of multiple genetic regions in the expression of CHD. Although we have associated some variants in the region of fibrillin 2 with CHD in a subset of dogs,...

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Bibliographic Details
Published in:Journal of applied statistics 2012-08, Vol.39 (8), p.1719-1731
Main Authors: Zhu, Lan, Chen, Su, Jiang, Zhuoxin, Zhang, Zhiwu, Ku, Hung-Chih, Li, Xuesong, McCann, Melinda, Harris, Steve, Lust, George, Jones, Pual, Todhunter, Rory
Format: Article
Language:English
Subjects:
canine hip dysplasia
Chromosomes
Deformities
Dogs
Gene expression
Gene loci
Genes
Genetics
Hip dislocation
Linkages
Loci
Monte Carlo methods
Monte Carlo simulation
multipoint linkage analysis
Nucleotides
quantitative trait loci
reversible jump Markov chain Monte Carlo
single nucleotide polymorphism
Studies
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Summary:Canine hip dysplasia (CHD) is characterized by hip laxity and subluxation that can lead to hip osteoarthritis. Studies have shown the involvement of multiple genetic regions in the expression of CHD. Although we have associated some variants in the region of fibrillin 2 with CHD in a subset of dogs, no major disease-associated gene has been identified. The focus of this study is to identify quantitative trait loci (QTL) associated with CHD. Two sequential multipoint linkage analyses based on a reversible jump Markov chain Monte Carlo approach were applied on a cross-breed pedigree of 366 dogs. Hip radiographic trait (Norberg Angle, NA) on both hips of each dog was tested for linkage to 21,455 single nucleotide polymorphisms across 39 chromosomes. Putative QTL for the NA was found on 11 chromosomes (1, 2, 3, 4, 7, 14, 19, 21, 32, 36, and 39). Identification of genes in the QTL region(s) can assist in identification of the aberrant genes and biochemical pathways involving hip dysplasia in both dogs and humans.
ISSN:0266-4763
1360-0532
DOI:10.1080/02664763.2012.673121