Peri-infarct zone pacing to prevent adverse left ventricular remodelling in patients with large myocardial infarction

• Published in: European heart journal 2016-02, Vol.37 (5), p.484-493
• Main Authors: Stone, Gregg W, Chung, Eugene S, Stancak, Branislav, Svendsen, Jesper H, Fischer, Trent M, Kueffer, Fred, Ryan, Thomas, Bax, Jeroen, Leon, Angel
• Format: Article
• Language: English
• Subjects: Cardiac Resynchronization Therapy - methods; Female; Heart Failure - physiopathology; Heart Failure - therapy; Humans; Male; Middle Aged; Myocardial Infarction - physiopathology; Myocardial Infarction - therapy; Prospective Studies; Stroke Volume - physiology; Treatment Outcome; Ventricular Remodeling - physiology
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/eurheartj/ehv436

We sought to determine whether peri-infarct pacing prevents left ventricular (LV) remodelling and improves functional and clinical outcomes in patients with large first myocardial infarction (MI). A total of 126 patients at 27 international sites within 10 days of onset of anterior or non-anterior MI with creatine phosphokinase >3000 U/L and QRS duration ≤120 ms were randomized 1:1:1 to dual-site biventricular pacing vs. single-site LV only pacing vs. non-implanted control. The primary endpoint was the echocardiographic core laboratory-assessed change in LV end-diastolic volume (ΔLVEDV) from baseline to 18 months between the pooled pacing therapy groups and the control group. ΔLVEDV increased by 15.3 ± 28.6 mL in the control group and by 16.7 ± 30.5 mL in the pooled pacing groups during follow-up (adjusted mean difference (95% CI) = 0.6 (-12.3, 13.5) mL, P = 0.92). There were also no significant between-group differences in the change in LV end-systolic volume or ejection fraction over time. Quality of life, as assessed by the Minnesota Living with Heart Failure (HF) and European Quality of Life-5 Dimension questionnaires and New York Heart Association class, was also similar between groups during 18-month follow-up. Six-minute walk distance improved during follow-up to an equal degree between groups, and there were no significant differences in the 18-month rates of death or HF hospitalization between the pooled pacing therapy vs. control groups (17.4 vs. 21.7% respectively, P = 0.59). In the present multicentre, randomized trial, peri-infarct pacing did not prevent LV remodelling or improve functional or clinical outcomes during 18-month follow-up in patients with large first MI. NCT01213251.