50 Years of Emmonsia Disease in Humans: The Dramatic Emergence of a Cluster of Novel Fungal Pathogens: e1005198

A Leap from Obscurity to Global Medical Importance Over the last four decades, reports have emerged of patients with unusual mycoses: in the laboratory, cultures have isolated molds with asexual reproductive structures that resembled Emmonsia, but clinical and histopathological pictures were more co...

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Published in:PLoS pathogens 2015-11, Vol.11 (11)
Main Authors: Schwartz, Ilan S, Kenyon, Chris, Feng, Peiying, Govender, Nelesh P, Dukik, Karolina, Sigler, Lynne, Jiang, Yanping, Stielow, J Benjamin, Muñoz, José F, Cuomo, Christina A, Botha, Alfred, Stchigel, Alberto M, Hoog, G Sybrende
Format: Article
Language:English
Subjects:
Antiretroviral agents
Corticoids
Disease
Fatalities
Funding
Fungi
Genomes
Infections
Literature reviews
Microscopy
Patients
Phylogenetics
Scholarships & fellowships
Yeast
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Summary:A Leap from Obscurity to Global Medical Importance Over the last four decades, reports have emerged of patients with unusual mycoses: in the laboratory, cultures have isolated molds with asexual reproductive structures that resembled Emmonsia, but clinical and histopathological pictures were more compatible with blastomycosis or histoplasmosis than adiaspiromycosis (Fig 2). Vertical bars represent number of cases during 5-year intervals, as determined by literature review.\n Disease results from tissue invasion [28], although a contribution of host response to pathogenesis is suggested by apparent unmasking immune reconstitution inflammatory syndrome in some HIV-infected patients who develop stigmata of disease upon initiating antiretroviral treatment [17]. Adiaspiromycosis is generally self-limiting, and fatalities are exceptional [29-31]. Because this disease results from host response, corticosteroids have been advocated in severe cases; the role of antifungals remains uncertain [3,31,32].
ISSN:1553-7366
1553-7374
DOI:10.1371/journal.ppat.1005198