Heritability and familiality of neurological soft signs: evidence from healthy twins, patients with schizophrenia and non-psychotic first-degree relatives

Neurological soft signs (NSS) have long been considered potential endophenotypes for schizophrenia. However, few studies have investigated the heritability and familiality of NSS. The present study examined the heritability and familiality of NSS in healthy twins and patient-relative pairs. The abri...

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Bibliographic Details
Published in:Psychological medicine 2016-01, Vol.46 (1), p.117-123
Main Authors: Xu, T., Wang, Y., Li, Z., Huang, J., Lui, S. S. Y., Tan, S.-P., Yu, X., Cheung, E. F. C., He, M.-G., Ott, J., Gur, R. E., Gur, R. C., Chan, R. C. K.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Children & youth
Disease Susceptibility
Diseases in Twins - complications
Diseases in Twins - physiopathology
Endophenotypes
Families & family life
Family
Female
Genetics
Heritability
Humans
Male
Mental disorders
Monozygotic
Motor Skills Disorders - etiology
Motor Skills Disorders - physiopathology
Neurology
Original Articles
Psychosis
Schizophrenia
Schizophrenia - complications
Schizophrenia - physiopathology
Sensation Disorders - etiology
Sensation Disorders - physiopathology
Siblings
Twins
Young Adult
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Summary:Neurological soft signs (NSS) have long been considered potential endophenotypes for schizophrenia. However, few studies have investigated the heritability and familiality of NSS. The present study examined the heritability and familiality of NSS in healthy twins and patient-relative pairs. The abridged version of the Cambridge Neurological Inventory was administered to 267 pairs of monozygotic twins, 124 pairs of dizygotic twins, and 75 pairs of patients with schizophrenia and their non-psychotic first-degree relatives. NSS were found to have moderate but significant heritability in the healthy twin sample. Moreover, patients with schizophrenia correlated closely with their first-degree relatives on NSS. Taken together, the findings provide evidence on the heritability and familiality of NSS in the Han Chinese population.
ISSN:0033-2917
1469-8978
DOI:10.1017/S0033291715001580