The Muscle Metabolome Differs between Healthy and Frail Older Adults

Populations around the world are aging rapidly. Age-related loss of physiological functions negatively affects quality of life. A major contributor to the frailty syndrome of aging is loss of skeletal muscle. In this study we assessed the skeletal muscle biopsy metabolome of healthy young, healthy o...

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Published in:	Journal of proteome research 2016-02, Vol.15 (2), p.499-509
Main Authors:	Fazelzadeh, Parastoo, Hangelbroek, Roland W. J, Tieland, Michael, de Groot, Lisette C. P. G. M, Verdijk, Lex B, van Loon, Luc J. C, Smilde, Age K, Alves, Rodrigo D. A. M, Vervoort, Jacques, Müller, Michael, van Duynhoven, John P. M, Boekschoten, Mark V
Format:	Article
Language:	English
Subjects:	Afdeling Humane voeding Aged Aged, 80 and over amino acid metabolism Amino Acids - metabolism Analysis of Variance Biochemie Biochemistry Biofysica Biophysics biopsy branched chain amino acids Carboxylic Acids - metabolism Chair Nutrition and Health over the Lifecourse Chair Nutrition Metabolism and Genomics Cultural Geography elderly Exercise Female Frail Elderly Gas Chromatography-Mass Spectrometry genes Global Nutrition HNE Nutrition and Health over the Lifecourse HNE Nutrition, Metabolism and Genomics HNE Voeding en Gezondheid in de Levenscyclus HNE Voeding, Metabolisme en Genomics Human Nutrition Human Nutrition & Health Human Nutrition (HNE) Humane Voeding Humane Voeding & Gezondheid Humans Laboratorium voor Biofysica Leerstoelgroep Culturele Geografie Male metabolites Metabolome Metabolomics - methods mitochondria muscle fibers Muscle, Skeletal - metabolism muscles Nutrition, Metabolism and Genomics Principal Component Analysis proteome quality of life skeletal muscle VLAG Voeding, Metabolisme en Genomica Wereldvoeding Young Adult
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