Role of Inflammation and Immunity in Hypertension: Recent Epidemiological, Laboratory, and Clinical Evidence

Inflammation has been shown to play an important role in the mechanisms involved in the pathogenesis of hypertension. Accordingly, innate and adaptive immune responses participate in blood pressure elevation. Here, we describe recent immunity studies focusing on novel inflammatory mechanisms during...

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Bibliographic Details
Published in:Current Hypertension Reports 2016-03, Vol.18 (3), p.21-21, Article 21
Main Authors: Caillon, Antoine, Schiffrin, Ernesto L.
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - immunology
Cardiology
Family Medicine
General Practice
Humans
Hypertension
Hypertension - epidemiology
Hypertension - immunology
Immunity, Innate - immunology
Inflammation - immunology
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Nephrology
Pathogenesis of Hypertension (W Elliott and R Santos
Primary Care Medicine
Section Editors
T-Lymphocytes - immunology
Toll-Like Receptors - immunology
Topical Collection on Pathogenesis of Hypertension
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Summary:Inflammation has been shown to play an important role in the mechanisms involved in the pathogenesis of hypertension. Accordingly, innate and adaptive immune responses participate in blood pressure elevation. Here, we describe recent immunity studies focusing on novel inflammatory mechanisms during the hypertensive process. Different subpopulations of cells involved in innate and adaptive immune responses, such as monocyte/macrophages and dendritic cells on the one hand and B and T lymphocytes on the other hand, play roles leading to vascular injury in hypertension. Innate lymphoid cells, including natural killer cells and γ/δ T cells, have recently been demonstrated to participate in hypertensive mechanisms triggering vascular inflammation. In summary, we discuss the evidence of interaction of these different inflammatory and immune components in both experimental models and in humans during the development of hypertension.
ISSN:1522-6417
1534-3111
DOI:10.1007/s11906-016-0628-7