An evaluation of motor evoked potential surrogate endpoints during intracranial vascular procedures

Highlights • Motor evoked potentials (MEPs) during intracranial vascular surgeries are used as surrogate endpoints to predict the efficacy of interventions to avoid new postoperative deficits. • The probability of a new postoperative deficit was reduced by 60% for reversible, as compared to irrevers...

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Bibliographic Details
Published in:Clinical neurophysiology 2016-02, Vol.127 (2), p.1717-1725
Main Authors: Holdefer, R.N, MacDonald, D.B, Guo, L, Skinner, S.A
Format: Article
Language:English
Subjects:
Aneurysm
Biomarker
Biomarkers
Cerebrovascular Disorders - diagnosis
Cerebrovascular Disorders - surgery
Evoked Potentials, Motor - physiology
Humans
Intraoperative neurophysiological monitoring
Monitoring, Intraoperative - methods
Motor evoked potentials
Neurology
Neurosurgical Procedures - methods
Opportunity cost
Reversible signal change
Surrogate endpoint
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Summary:Highlights • Motor evoked potentials (MEPs) during intracranial vascular surgeries are used as surrogate endpoints to predict the efficacy of interventions to avoid new postoperative deficits. • The probability of a new postoperative deficit was reduced by 60% for reversible, as compared to irreversible, MEP deteriorations in a meta-analysis of recent studies. • The efficacy of interventions in recovering MEP deteriorations was negatively correlated with new postoperative deficits in motor strength.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2015.09.133