Recent insights into the role of autophagy in the pathogenesis of rheumatoid arthritis

Autophagy appears to play a dual role in eukaryotic cells. It manifests cytoprotective effects through the regulation of catabolic processes and the clearance of pathogens; however, a correlation between autophagy and the pathogenesis of autoimmune/autoinflammatory conditions has recently been descr...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2016-03, Vol.55 (3), p.403-410
Main Authors: Dai, Yujie, Hu, Shaoxian
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - physiopathology
Autoimmunity - physiology
Autophagy - immunology
Autophagy - physiology
Cells, Cultured
Chondrocytes - immunology
Chondrocytes - metabolism
Cytokines - immunology
Cytokines - metabolism
Female
Fibroblasts - immunology
Fibroblasts - metabolism
Humans
Immunity, Innate - physiology
Male
Osteoclasts - cytology
Osteoclasts - metabolism
Prognosis
Role
Synovial Membrane - immunology
Synovial Membrane - metabolism
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Summary:Autophagy appears to play a dual role in eukaryotic cells. It manifests cytoprotective effects through the regulation of catabolic processes and the clearance of pathogens; however, a correlation between autophagy and the pathogenesis of autoimmune/autoinflammatory conditions has recently been described. Autophagy has emerged as a mediator in the pathogenesis of RA. Autophagy may regulate apoptosis resistance and hyperplasia in synovial fibroblasts, promote osteoclastogenesis and stimulate osteoclast-mediated bone resorption through the delivery of citrullinated peptides to MHC compartments, which results in the activation of the innate and adaptive immune response, thereby resulting in RA. Given the likely importance of autophagy in the pathogenesis of RA, here we reviewed the detailed mechanisms concerning the pathogenicity of autophagy and autophagy proteins in RA.
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/kev337