Use of preoperative performance status and hemoglobin concentration to predict overall survival for patients aged ≥75 years after radical cystectomy for treatment of bladder cancer

Background The standard of care for treatment of localized muscle-invasive bladder cancer (MIBC) is radical cystectomy (RC). The patient’s condition may affect management of MIBC, especially for elderly patients with more comorbid conditions and lower performance status. We retrospectively evaluated...

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Bibliographic Details
Published in:International journal of clinical oncology 2016-02, Vol.21 (1), p.139-147
Main Authors: Hara, Takahiko, Matsuyama, Hideyasu, Kamiryo, Yoriaki, Hayashida, Shigeaki, Yamamoto, Norio, Nasu, Takahito, Joko, Keiji, Baba, Yoshikazu, Suga, Akinobu, Yamamoto, Mitsutaka, Aoki, Akihiko, Takai, Kimio, Yoshihiro, Satoru, Konishi, Motohiko, Sakano, Sigeru, Imoto, Katsuhiko, Tei, Yasuhide, Yamaguchi, Shiro, Yano, Seiji
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Bladder cancer
Cancer Research
Cancer surgery
Cystectomy - adverse effects
Cystectomy - mortality
Female
Follow-Up Studies
Health Status
Hemoglobins - metabolism
Humans
Lymph Node Excision - adverse effects
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Older people
Oncology
Original Article
Predictive Value of Tests
Prognosis
Retrospective Studies
Surgical Oncology
Surgical outcomes
Survival Rate
Urinary Bladder Neoplasms - mortality
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - surgery
Urinary Diversion
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Summary:Background The standard of care for treatment of localized muscle-invasive bladder cancer (MIBC) is radical cystectomy (RC). The patient’s condition may affect management of MIBC, especially for elderly patients with more comorbid conditions and lower performance status. We retrospectively evaluated the association between clinicopathological data and outcomes for patients with bladder cancer (BCa) treated by RC. We particularly focused on elderly patients (age ≥75 years) with BCa. Methods We enrolled 254 patients with BCa who underwent RC and urinary diversion with or without pelvic lymph node dissection. We assessed perioperative complications and clinicopathological data affecting overall survival (OS) after RC. Results The incidence of complications was 34.3 %, and that of severe complications (Grade 3–5) was 16.5 %. The elderly group experienced more severe complications ( P  = 0.042). Median follow-up was 43.0 months (range 1.0–155.6). Five-year OS after RC was 62.7 %. OS after RC was no different for patients aged ≥75 and
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-015-0857-9