Association between antidepressants and falls in Parkinson’s disease

Parkinson’s disease (PD) patients have an increased risk of falls resulting in important social and economical consequences. Risk factors for falls include the use of psychotropic drugs, which are used for the treatment of PD neuropsychiatric symptoms. We aimed to determine the association between p...

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Bibliographic Details
Published in:Journal of neurology 2016-01, Vol.263 (1), p.76-82
Main Authors: Martinez-Ramirez, Daniel, Giugni, Juan C., Almeida, Leonardo, Walz, Roger, Ahmed, Bilal, Chai, Fiona A., Rundle-Gonzalez, Valerie, Bona, Alberto R., Monari, Erin, Wagle Shukla, Aparna, Hess, Christopher W., Hass, Chris J., Okun, Michael S.
Format: Article
Language:English
Subjects:
Accidental Falls - statistics & numerical data
Aged
Aged, 80 and over
Antidepressive Agents - therapeutic use
Antipsychotic Agents - therapeutic use
Benzodiazepines - therapeutic use
Central Nervous System Stimulants - therapeutic use
Cross-Sectional Studies
Female
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neurology
Neuroradiology
Neurosciences
Original Communication
Parkinson Disease - drug therapy
Parkinson's disease
Psychotropic Drugs - adverse effects
Psychotropic Drugs - therapeutic use
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Summary:Parkinson’s disease (PD) patients have an increased risk of falls resulting in important social and economical consequences. Risk factors for falls include the use of psychotropic drugs, which are used for the treatment of PD neuropsychiatric symptoms. We aimed to determine the association between psychotropic drug use and falls in a PD cohort. A cross-sectional study from the NPF QII study UF site was conducted. Subjects reported presence and frequency of falls in the prior year. Frequency was scored from 0 (no falls) to 4 (falling daily). Antidepressants, antipsychotics, cognitive enhancers/stimulants, and benzodiazepines were considered psychotropics. Forty percent of the 647 subjects included had a fall in the previous year. Fallers were found to have clinical signs of a more advanced disease. After adjusting for confounding variables, the regression analysis showed that use of antidepressants alone (adjusted OR 2.2, CI 95 % 1.3–3.8, p  = 0.04), benzodiazepines alone (adjusted OR 2.0, CI 95 % 1.1–3.5, p  = 0.02), and the combination of antidepressants with benzodiazepines (adjusted OR 4.1, CI 95 % 2.0–8.3, p  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-015-7947-5