Intracranial meningioma surgery in the elderly (over 65 years): prognostic factors and outcome

Background Meningiomas are more prevalent in elderly individuals; however, the surgical outcome and prognostic factors in this age group are unclear. This retrospective study aimed to identify the prognostic factors of elderly patients with intracranial meningiomas who underwent surgical resection....

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Bibliographic Details
Published in:Acta neurochirurgica 2015-09, Vol.157 (9), p.1549-1557
Main Authors: Chen, Zhi-Yi, Zheng, Chuan-Hua, Tang Li, Su, Xiao-Yan, Lu, Gui-Hua, Zhang, Chao-Yuan, Xiao, Shao-Wen, Tan, Yuan-Fu
Format: Article
Language:English
Subjects:
Age Factors
Aged
Clinical Article - Brain Tumors
Female
Humans
Interventional Radiology
Male
Medicine
Medicine & Public Health
Meningeal Neoplasms - surgery
Meningioma - surgery
Minimally Invasive Surgery
Neurology
Neuroradiology
Neurosurgery
Neurosurgical Procedures - adverse effects
Neurosurgical Procedures - statistics & numerical data
Surgical Orthopedics
Survival Analysis
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Summary:Background Meningiomas are more prevalent in elderly individuals; however, the surgical outcome and prognostic factors in this age group are unclear. This retrospective study aimed to identify the prognostic factors of elderly patients with intracranial meningiomas who underwent surgical resection. Methods Eighty-six patients (aged ≥65) diagnosed with an intracranial meningioma were surgically treated at our department. The clinical, radiological, and follow-up data were retrospectively reviewed. Univariate and multivariate logistic analyses were performed to identify relationships between factors [age, sex, neurological condition, concomitant disease, American Society of Anesthesiology (ASA) classification, preoperative Karnofsky Performance Scale (KPS) score, tumor location and size, peritumoral edema, and Simpson resection grade] and outcome. Results One patient (1.2 %) died within 30 days of surgery. The morbidity rate was 37.2 %. Postoperative morbidities occurred more frequently in the patients with preoperative neurological deficits than in those without ( p  = 0.049). Univariate analysis identified significant relationships between a low KPS score (≤70) at discharge and preoperative neurological deficits, low preoperative KPS score (≤70), and critical tumor location ( p  
ISSN:0001-6268
0942-0940
DOI:10.1007/s00701-015-2502-9