Current use and perspective of indocyanine green clearance in liver diseases

Abstract Indocyanine green (ICG) is a water-soluble anionic compound that binds to plasma proteins after intravenous administration. It is selectively taken up at the first pass by hepatocytes and excreted unchanged into the bile. With the development of ICG elimination measurement by spectrophotome...

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Bibliographic Details
Published in:Anaesthesia critical care & pain medicine 2016-02, Vol.35 (1), p.49-57
Main Authors: Levesque, Eric, Martin, Eléonore, Dudau, Daniela, Lim, Chetana, Dhonneur, Gilles, Azoulay, Daniel
Format: Article
Language:English
Subjects:
Anesthesia & Perioperative Care
Coloring Agents - pharmacokinetics
Humans
Indocyanine Green - pharmacokinetics
Indocyanine green clearance
Liver
Liver Diseases - diagnosis
Liver Diseases - metabolism
Liver function
Liver Function Tests - methods
Postoperative Care
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Summary:Abstract Indocyanine green (ICG) is a water-soluble anionic compound that binds to plasma proteins after intravenous administration. It is selectively taken up at the first pass by hepatocytes and excreted unchanged into the bile. With the development of ICG elimination measurement by spectrophotometry, the ICG retention test has become a safe, rapid, reproducible, inexpensive and noninvasive tool for the assessment of liver function. Clinical evidence suggests that the ICG retention test can enable the establishment of tailored management strategies by providing prognostic information. In particular, this method has been evaluated as a prognostic marker in patients with advanced cirrhosis or awaiting liver transplantation. In addition, it is used as a marker of portal hypertension in cirrhotic patients, as a prognostic factor in intensive care units and for the assessment of liver function in patients undergoing liver surgery. Since recent technology enables ICG-PDR to be measured noninvasively at the bedside, this parameter is an attractive addition to liver function and regional haemodynamic monitoring. However, the current state-of-the-art as concerns this technology remains at a low level of evidence and thorough assessment is required.
ISSN:2352-5568
2352-5568
DOI:10.1016/j.accpm.2015.06.006