Continuation and discontinuation of benzodiazepine prescriptions: A cohort study based on a large claims database in Japan

Abstract Although benzodiazepines (BZDs) are often prescribed to treat a wide range of psychiatric and neurological conditions, they are also associated with various harms and risks including dependence. However the frequency of its continued use in the real world has not been well studied, especial...

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Bibliographic Details
Published in:Psychiatry research 2016-03, Vol.237, p.201-207
Main Authors: Takeshima, Nozomi, Ogawa, Yusuke, Hayasaka, Yu, Furukawa, Toshi A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Benzodiazepine
Benzodiazepines - therapeutic use
Cohort Studies
Databases, Factual - trends
Drug Prescriptions
Female
Follow-Up Studies
Humans
Insurance Claim Reporting - trends
Japan - epidemiology
Kaplan-Meier survival analysis
Long-term use
Longitudinal Studies
Longitudinal study
Male
Middle Aged
Psychiatry
Psychotropic Drugs - therapeutic use
Young Adult
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Summary:Abstract Although benzodiazepines (BZDs) are often prescribed to treat a wide range of psychiatric and neurological conditions, they are also associated with various harms and risks including dependence. However the frequency of its continued use in the real world has not been well studied, especially at longer follow-ups. The aim of this study was to clarify the frequency of long-term BZD use among new BZD users over longer follow-ups and to identify its predictors. We conducted a cohort study to examine how frequently new BZD users became chronic users, based on a large claims database in Japan from January 2005 to June 2014. We used Cox proportional hazards models to identify potential predictors. A total 84,412 patients with new BZD prescriptions were included in our cohort. Among them, 35.8% continued to use BZD for three months, 15.2% for one year and 4.9% for eight years without ever attaining three months of no BZD prescription. The confirmed predictors for long-term BZD use were older age, psychiatrist-prescriber, regular use, high dose of BZD, and concomitant prescription of psychotropic drugs. When we consider BZD use, we have to keep in mind these figures and avoid these predictors as much as possible.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2016.01.040