The inflammatory markers CRP, IL-6, and IL-10 are associated with cognitive function—data from the Berlin Aging Study II

Abstract Inflammation may be an underlying mechanism in cognitive decline. The present study investigated the relationship between cognitive function and the inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and IL-10 in a nonclinical sample of elderly adults. Serum levels of CRP, I...

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Bibliographic Details
Published in:Neurobiology of aging 2016-02, Vol.38, p.112-117
Main Authors: Tegeler, Christina, O'Sullivan, Julie Lorraine, Bucholtz, Nina, Goldeck, David, Pawelec, Graham, Steinhagen-Thiessen, Elisabeth, Demuth, Ilja
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
C-Reactive Protein
Cognition - physiology
Cognitive function
Cytokine
Executive function
Executive Function - physiology
Female
Humans
Immunity, Innate
Inflammation
Inflammation Mediators - blood
Interleukin-10 - blood
Interleukin-6 - blood
Internal Medicine
Linear Models
Male
Memory
Middle Aged
Neurology
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Summary:Abstract Inflammation may be an underlying mechanism in cognitive decline. The present study investigated the relationship between cognitive function and the inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and IL-10 in a nonclinical sample of elderly adults. Serum levels of CRP, IL-6, and IL-10 were measured in n = 1312 elderly adults (60–85 years, 50.5% females) who underwent comprehensive neuropsychological testing. Multiple linear regression analysis was conducted and adjusted for various demographic and clinical factors. Levels of IL-6, IL-10, and CRP were negatively associated with a composite score of executive function and processing speed, whereas the IL-6 to IL-10 ratio was not predictive for executive function and processing speed. No associations were found between inflammatory markers and verbal episodic memory. These findings suggest a relationship between higher proinflammatory and anti-inflammatory activation of the innate immune system and executive function within the normal range. Further research is needed to examine the relevance of an inflammatory pathway as a potential therapeutic target.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2015.10.039