A Hollow Foldecture with Truncated Trigonal Bipyramid Shape from the Self-Assembly of an 11-Helical Foldamer

The creation of self‐assembling microscale architectures that possess new and useful physical properties remains a significant challenge. Herein we report that an 11‐helical foldamer self‐assembles in a controlled manner to form a series of 3D foldectures with unusual three‐fold symmetrical shapes t...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2015-11, Vol.54 (45), p.13204-13207
Main Authors: Eom, Jae-Hoon, Gong, Jintaek, Kwon, Sunbum, Jeon, Aram, Jeong, Rokam, Driver, Russell W., Lee, Hee-Seung
Format: Article
Language:English
Subjects:
Assembling
Biocompatibility
Containment
Containment vessels
Crystal structure
Diffraction
foldamers
hollow nanostructures
host-guest systems
Models, Molecular
molecular architecture
Molecular Conformation
Morphology
Particle Size
Peptides - chemistry
Physical properties
Powder
Powder Diffraction
Protein Folding
Proteins
Proteins - chemistry
Self assembly
Surface Properties
Three dimensional
Utilities
Vehicles
X-ray diffraction
X-rays
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Summary:The creation of self‐assembling microscale architectures that possess new and useful physical properties remains a significant challenge. Herein we report that an 11‐helical foldamer self‐assembles in a controlled manner to form a series of 3D foldectures with unusual three‐fold symmetrical shapes that are distinct from those generated from 12‐helical foldamers. The foldamer packing motif was revealed by powder X‐ray diffraction technique, and provides an important link between the molecular‐level symmetry and the microscale morphologies. The utility of foldectures with hollow interiors as robust and well‐defined supramolecular hosts was demonstrated for inorganic, organic, and even protein guests. This work will pave the way for the design of functional foldectures with greater 3D shape diversity and for the development of biocompatible delivery vehicles and containment vessels. Gigantic molecular containers: The self‐assembly of an 11‐helical foldamer provided highly crystalline, hollow foldectures with truncated trigonal bipyramid shape. These foldectures are molecular hosts in a way reminiscent of a biological microcompartment.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201504248