The potential role of strontium ranelate in treating particle-induced osteolysis

[Display omitted] Ultra high molecular weight polyethylene (UHMWPE) wear-particle-induced osteolysis is one of the major issues affecting the long-term survival of total joint prostheses. Currently, there are no effective therapeutic options to prevent osteolysis from occurring. The aim of this stud...

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Bibliographic Details
Published in:Acta biomaterialia 2015-07, Vol.20, p.147-154
Main Authors: Lu, Yung-Chang, Chang, Ting-Kuo, Yeh, Shu-Ting, Fang, Hsu-Wei, Lin, Chun-Yen, Hsu, Lin-I, Huang, Chun-Hsiung, Huang, Chang-Hung
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Biocompatibility
Biomedical materials
Bones
Cell Count
Disease Models, Animal
Female
Mice, Inbred C57BL
Molecular weight
Murine calvarial model
Osteoclasts - drug effects
Osteoclasts - pathology
Osteolysis - chemically induced
Osteolysis - drug therapy
Osteolysis - pathology
Particle Size
Particle-induced osteolysis
Polyethylenes
Polyethylenes - adverse effects
Skull
Skull - diagnostic imaging
Skull - drug effects
Skull - pathology
Strontium
Strontium ranelate
Surgical implants
Thiophenes - pharmacology
Thiophenes - therapeutic use
Wear debris
X-Ray Microtomography
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Summary:[Display omitted] Ultra high molecular weight polyethylene (UHMWPE) wear-particle-induced osteolysis is one of the major issues affecting the long-term survival of total joint prostheses. Currently, there are no effective therapeutic options to prevent osteolysis from occurring. The aim of this study was to evaluate the role of strontium ranelate (SR) in reducing the risk of particle-induced osteolysis. Forty-eight C57BL/6J ultra-high molecular weight polyethylene (UHMWPE) particle-induced murine calvarial osteolysis models were used. The mice were randomized into four groups as: sham (Group 1), UHMWPE particles (Group 2), and SR with UHMWPE particles (Group 3 and Group 4). Groups 1 to 3 were sacrificed at two weeks and group 4 was sacrificed at the fourth week. The skulls were then analyzed with a high-resolution micro-CT. Histological evaluation was then conducted and osteoclast numbers were analyzed for comparison. Based on the micro-CT, percentage bone volume and trabecular thickness were found to be significantly higher in Group 4 than in Group 2 (p
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2015.03.034