Gd-loaded-RBCs for the assessment of tumor vascular volume by contrast-enhanced-MRI

Abstract The assessment of the fractional vascular volume ( v V ) in the tumor area is of great interest in the characterization of tumor and it can be useful to monitor the outcome of anti-angiogenetic therapies. The high spatial and temporal resolution of Magnetic Resonance Imaging makes it the el...

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Bibliographic Details
Published in:Biomaterials 2015-07, Vol.58, p.82-92
Main Authors: Ferrauto, Giuseppe, Di Gregorio, Enza, Dastrù, Walter, Lanzardo, Stefania, Aime, Silvio
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Assessments
Biocompatibility
Biocompatible Materials
Biomedical materials
Brain - pathology
Contrast agents
Contrast Media - chemistry
Dentistry
Erythrocytes - drug effects
Female
Gadolinium - chemistry
Imaging
Magnetic Resonance Imaging
Mice
Mice, Inbred BALB C
Microscopy, Fluorescence
Monitors
Muscles - pathology
Neoplasms - blood supply
Neovascularization, Pathologic
Platelet Endothelial Cell Adhesion Molecule-1 - metabolism
Surgical implants
Tumor Burden
Tumors
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Summary:Abstract The assessment of the fractional vascular volume ( v V ) in the tumor area is of great interest in the characterization of tumor and it can be useful to monitor the outcome of anti-angiogenetic therapies. The high spatial and temporal resolution of Magnetic Resonance Imaging makes it the election imaging modality to monitor in vivo the vascular volume changes. Commonly used MRI methods to obtain this information rely on the administration of contrast agents that modify the bulk water relaxation times but, unfortunately, they can provide only an estimate of v V since they are not fully retained in the vascular space. Herein, Gd-loaded Red Blood Cells (Gd-RBCs) are proposed as a contrast agent able to provide quantitative information on tumor vascularization. Being Gd-RBCs fully retained in the vascular space, the proposed method does not suffer for the limitations associated to the use of extracellular Gd-agents that quickly extravasate in the leaky tumor vasculature. Furthermore, the long half-life and biocompatibility of Gd-RBCs allows repeating the measurement many times upon their administration; this ensures the possibility to in vivo evaluate the change of vascular volume during tumor growth. For these reasons, Gd-RBCs may represent a highly biocompatible imaging reporter of vasculature, able to quantitatively assess changes in the vascular volume in the ROI.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2015.04.026