In extremely preterm infants, do the Movement Assessment of Infants and the Alberta Infant Motor Scale predict 18-month outcomes using the Bayley-III?

• Published in: Early human development 2016-03, Vol.94, p.13-17
• Main Authors: Lefebvre, Francine, Gagnon, Marie-Michèle, Luu, Thuy Mai, Lupien, Geneviève, Dorval, Véronique
• Format: Article
• Language: English
• Subjects: Adult; Advanced Basic Science; Alberta Infant Motor Scale; Bayley Scales of Infant and Toddler Development; Child Development; Developmental Disabilities - diagnosis; Developmental Disabilities - epidemiology; Extremely preterm infant; Female; Humans; Infant outcome; Infant, Extremely Premature - growth & development; Infant, Extremely Premature - physiology; Infant, Newborn; Movement; Movement Assessment of Infants; Neonatal and Perinatal Medicine; Neurologic Examination - methods; Severity of Illness Index
• ISSN: 0378-3782; 1872-6232
• DOI: 10.1016/j.earlhumdev.2016.01.012

Abstract Background Extremely preterm infants are at high-risk for neurodevelopmental disabilities. The Movement Assessment of Infants (MAI) and the Alberta Infant Motor Scale (AIMS) have been designed to predict outcome with modest accuracy with the Bayley-I or Bayley-II. Aims To examine and compare the predictive validity of the MAI and AIMS in determining neurodevelopmental outcome with the Bayley-III. Design Retrospective cohort study of 160 infants born at ≤ 28 weeks gestation. Method At their corrected age, infants underwent the MAI at 4 months, the AIMS at 4 and 10–12 months, and the Bayley-III and neurological examination at 18 months. Sensitivity and specificity were calculated. Results Infants had a mean gestation of 26.3 ± 1.4 weeks and birth weight of 906 ± 207 g. A high-risk score (≥ 14) for adverse outcome was obtained by 57% of infants on the MAI. On the AIMS, a high-risk score (< 5th percentile) was obtained by 56% at 4 months and 30% at 10–12 months. At 18 months, infants with low-risk scores on either the MAI or AIMS had higher cognitive, language, and motor Bayley-III scores than those with high-risk scores. They were less likely to have severe neurodevelopmental impairment. To predict Bayley-III scores < 70, sensitivity and specificity were 91% and 49%, respectively, for the MAI and 78% and 48%, respectively, for the AIMS. Conclusions Extremely preterm infants with low-risk MAI at 4 months or AIMS scores at 4 or 10–12 months had better outcomes than those with high-risk scores. However, both tests lack specificity to predict individual neurodevelopmental status at 18 months.