DNA Methylation Patterns in Peripheral Blood of Pregnant Women With Group B Streptococcus Colonization

The primary risk factor for neonatal Group B streptococcus (GBS) infection, which is the leading cause of infectious neonatal morbidity and mortality, is maternal colonization. However, no definitive maternal risk factors for GBS colonization have been identified and no systematic efforts have been...

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Bibliographic Details
Published in:Biological research for nursing 2015-07, Vol.17 (4), p.438-443
Main Authors: Wright, Michelle L., Ralph, Jody L., Korniewicz, Denise M.
Format: Article
Language:English
Subjects:
Adult
DNA Methylation
Female
Humans
Nursing
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy Complications, Infectious - genetics
Pregnancy Complications, Infectious - microbiology
Pregnancy Outcome
Pregnancy Trimester, Third - genetics
Real-Time Polymerase Chain Reaction
Risk Factors
Sequence Analysis, DNA
Streptococcal Infections - diagnosis
Streptococcal Infections - genetics
Streptococcus agalactiae - genetics
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Summary:The primary risk factor for neonatal Group B streptococcus (GBS) infection, which is the leading cause of infectious neonatal morbidity and mortality, is maternal colonization. However, no definitive maternal risk factors for GBS colonization have been identified and no systematic efforts have been made to prevent maternal colonization. The purpose of this exploratory secondary analysis was to evaluate genome-wide DNA methylation patterns in maternal peripheral blood early in pregnancy for association with GBS colonization status in the third trimester. Genome-wide DNA methylation was analyzed from 18 nulliparous GBS-positive and -negative women (n = 9/group) recruited for a previous study. No statistically significant differences in baseline characteristics or DNA methylation in peripheral blood were identified between GBS-positive and -negative women in early pregnancy. The results suggest that DNA methylation patterns in peripheral blood are not associated with risk for GBS colonization.
ISSN:1099-8004
1552-4175
DOI:10.1177/1099800415584996