Serum palmitoleate acts as a lipokine in subjects at high cardiometabolic risk

Abstract Background and aim Clinical data on the role as a lipokine of de novo lipogenesis-derived palmitoleic acid (C16:1n-7 cis ) in serum non-esterified fatty acids (palmitoleate) are scarce. We aimed to assess whether palmitoleate relates to cardiometabolic risk. Methods and results In this cros...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2016-03, Vol.26 (3), p.261-267
Main Authors: Merino, J, Sala-Vila, A, Plana, N, Girona, J, Vallve, J.C, Ibarretxe, D, Ros, E, Ferré, R, Heras, M, Masana, L
Format: Article
Language:English
Subjects:
Adiponectin - blood
Adipose Tissue - metabolism
Adult
Aged
Body Mass Index
C-Reactive Protein - metabolism
Cardiovascular
Cardiovascular Diseases - blood
Cardiovascular risk
Carotid Intima-Media Thickness
Cholesterol Ester Transfer Proteins - blood
Cross-Sectional Studies
Fatty Acid-Binding Proteins - metabolism
Fatty Acids, Monounsaturated - blood
Fatty Acids, Nonesterified - blood
Female
Humans
Insulin - blood
Lipogenesis
Lipogenesis - physiology
Lipokine
Male
Metabolic syndrome
Metabolic Syndrome - blood
Middle Aged
Non-alcoholic Fatty Liver Disease - blood
Palmitoleate
Phosphatidylcholine-Sterol O-Acyltransferase - blood
Prevalence
Retinol-Binding Proteins, Plasma - metabolism
Risk Factors
Waist Circumference
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Summary:Abstract Background and aim Clinical data on the role as a lipokine of de novo lipogenesis-derived palmitoleic acid (C16:1n-7 cis ) in serum non-esterified fatty acids (palmitoleate) are scarce. We aimed to assess whether palmitoleate relates to cardiometabolic risk. Methods and results In this cross-sectional study we included 358 individuals aged 30–65-years at high cardiovascular risk. We tested the association of palmitoleate (determined by gas chromatography) with metabolic syndrome (MS) and its components (defined by ATPIII criteria), fatty liver index (a surrogate of non-alcoholic fatty liver disease [NAFLD]), and subclinical atherosclerosis (determined as ultrasound-measured carotid intima-media thickness and arterial stiffness). Palmitoleate concentration was higher in women compared with men (median ± range interquartile, 1.36 ± 0.96 vs. 0.97 ± 0.77 μmol/L respectively, P  
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2015.12.008