Response to the influenza vaccine based on estradiol use in menopausal women

Abstract Objective To assess the impact of 17β-estradiol in modulating the response to the influenza vaccine in postmenopausal women. Methods A prospective cohort study was conducted with 46 healthy postmenopausal women aged 41–62 years without previous vaccination against the influenza virus. Evalu...

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Bibliographic Details
Published in:Vaccine 2016-03, Vol.34 (11), p.1358-1362
Main Authors: Itaborahy, Rejane Martins Ribeiro, Mancini, Dalva Assunção Portari, de Medeiros, Sebastião Freitas
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Antibodies, Viral - blood
Antibody
Colleges & universities
Dilution
Estradiol
Estradiol - therapeutic use
Estrogens
Female
Hemagglutination Inhibition Tests
Hormone Replacement Therapy
Humans
Immunoglobulins
Immunology
Influenza
Influenza vaccine
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza virus
Laboratories
Longitudinal Studies
Menopause
Menopause - drug effects
Middle Aged
Mortality
Orthomyxoviridae
Patients
Prospective Studies
Vaccines
Viruses
Womens health
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Summary:Abstract Objective To assess the impact of 17β-estradiol in modulating the response to the influenza vaccine in postmenopausal women. Methods A prospective cohort study was conducted with 46 healthy postmenopausal women aged 41–62 years without previous vaccination against the influenza virus. Evaluation of serum antibodies using hemagglutination inhibition and single radial hemolysis was performed at the Virology Laboratory of the Butantan Institute, São Paulo, Brazil, using serum samples collected at two time points: immediately before and one month after vaccination. Results In non-estradiol users ( n = 25), the median number of hemagglutination-inhibiting units (Log2 ) increased from 5.32 to 6.82 ( p = 0.003). In estradiol users ( n = 21), the median number of hemagglutination-inhibiting units (Log2 ) increased from 5.32 to 5.82 ( p = 0.149). The median hemolytic areas produced with the single radial hemolysis assay before and after the vaccine were 11 mm in both groups. Conclusion In postmenopausal women, estrogen therapy did not have a positive influence on the production of antibodies against the influenza virus after vaccination, at least based on the formulation, time period, and methods used for quantifying these antibodies in the present study.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.01.052