Preoperative lymphocyte-monocyte and platelet-lymphocyte ratios as predictors of overall survival in patients with bladder cancer undergoing radical cystectomy

Although pretreatment neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) are reportedly associated with clinical outcomes of many cancers, their roles in patients with bladder cancer (BCa) who undergo radical cystectomy (RC) have not been widely i...

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Published in:Tumor biology 2015-11, Vol.36 (11), p.8537-8543
Main Authors: Zhang, Gui-Ming, Zhu, Yao, Luo, Lei, Wan, Fang-Ning, Zhu, Yi-Ping, Sun, Li-Jiang, Ye, Ding-Wei
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomedical and Life Sciences
Biomedicine
Bladder cancer
Blood platelets
Blood Platelets - pathology
Cancer Research
Cystectomy
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Leukocyte Count
Lymphocytes - pathology
Male
Medical prognosis
Middle Aged
Monocytes - pathology
Neutrophils - pathology
Preoperative Period
Prognosis
Research Article
Urinary Bladder Neoplasms - blood
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - surgery
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Summary:Although pretreatment neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) are reportedly associated with clinical outcomes of many cancers, their roles in patients with bladder cancer (BCa) who undergo radical cystectomy (RC) have not been widely investigated. We analyzed relationships between preoperative NLR, LMR, PLR, and overall survival (OS) in 124 BCa patients undergoing RC. OS curves were drawn using the Kaplan–Meier method and evaluated using the log-rank test. Relationships between OS and potential confounding variables were determined using Cox’s proportional hazard regression model. Decreased LMR was associated with shorter OS ( P  = 0.012); OS in the low PLR group was significantly longer than that in the high PLR group ( P  = 0.029), and NLR was not significantly associated with oncological outcomes. However, after adjusting for confounding variables, patients in the high-LMR group indicated >30 % decreased mortality than the low-LMR group (hazard ratio 0.674; 95 % confidence interval 0.412–0.890; P  = 0.003), and PLR was not an independent predictor of OS. Our results show that preoperative LMR is a better prognostic factor in BCa patients undergoing RC, compared with NLR and PLR.
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-015-3613-x