CD4 super(+) T-Cell-Dependent Reduction in Hepatitis C Virus-Specific Neutralizing Antibody Responses After Coinfection With Human Immunodeficiency Virus

Background.Human immunodeficiency virus (HIV) infection leads to lower rates of hepatitis C virus (HCV) clearance after acute infection, higher HCV viremia, and accelerated progression of HCV-related fibrosis. The mechanisms underlying this acceleration of HCV progression by HIV are poorly understoo...

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Bibliographic Details
Published in:The Journal of infectious diseases 2015-09, Vol.212 (6)
Main Authors: Bailey, Justin R, Dowd, Kimberly A, Snider, Anna E, Osburn, William O, Mehta, Shruti H, Kirk, Gregory D, Thomas, David L, Ray, Stuart C
Format: Article
Language:English
Subjects:
Hepatitis C virus
Lentivirus
Retroviridae
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Summary:Background.Human immunodeficiency virus (HIV) infection leads to lower rates of hepatitis C virus (HCV) clearance after acute infection, higher HCV viremia, and accelerated progression of HCV-related fibrosis. The mechanisms underlying this acceleration of HCV progression by HIV are poorly understood, but HIV-induced dysfunction in the anti-HCV humoral immune response may play a role. Methods.To define the effect of HIV coinfection on the anti-HCV antibody response, we measured anti-HCV envelope binding antibody titers, neutralizing antibody (nAb) titers, and nAb breadth of serum from HCV-infected subjects isolated longitudinally before and after incident HIV infection. Results.A significant reduction in HCV envelope-specific binding antibody and nAb titers was detected in subjects with CD4 super(+) T-cell counts
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiv139