Increased DOI-induced head shakings in adult rats neonatally treated with MK-801

We examined the effects of neonatal treatment with MK-801 on 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced head shaking as well as [ 3H]ketanserin binding in adult rats. Neonatal rats were injected with MK-801 (0.25 mg/kg, s.c., twice daily) or with saline from postnatal days (PND) 7–1...

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Published in:Brain research. Developmental brain research 2000-11, Vol.124 (1), p.125-127
Main Authors: Kurumaji, Akeo, Aihara, Okihiko, Yamada, Satoru, Toru, Michio
Format: Article
Language:English
Subjects:
1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane
Amphetamines
Animals
Animals, Newborn - physiology
Dizocilpine Maleate - pharmacology
DOI
Drug Synergism
Dyskinesia, Drug-Induced - physiopathology
Excitatory Amino Acid Antagonists - pharmacology
Head - physiopathology
Head shaking
ketanserin
Ketanserin - metabolism
MK-801
Neonatal rat
NMDA receptor
Prefrontal Cortex - metabolism
Rats
Rats, Sprague-Dawley
Serotonin Antagonists - metabolism
Serotonin Receptor Agonists
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Summary:We examined the effects of neonatal treatment with MK-801 on 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced head shaking as well as [ 3H]ketanserin binding in adult rats. Neonatal rats were injected with MK-801 (0.25 mg/kg, s.c., twice daily) or with saline from postnatal days (PND) 7–18. At PND 60, a statistically significant increase in the frequency of head shaking induced by DOI (1.0 mg/kg, s.c.) was observed in the rats neonatally treated with MK-801, compared to saline-treated rats, without any change in the specific [ 3H]ketanserin binding in the frontal cortex. These results suggest that repeated NMDA receptor blockades during the critical period of brain development produce a long lasting hyper-responsiveness in the 5-HT 2A receptor-mediated behavior, interfering with the development of neural circuits related to the behavior.
ISSN:0165-3806
DOI:10.1016/S0165-3806(00)00107-3