Phagocytosis: An Immunobiologic Process

It has been a century since the death of Élie Metchnikoff, who championed the role of phagocytosis in cellular immunity. Whereas others had observed the uptake of particles by cells from simple to complex organisms, he grasped its significance in the host response to injury and infection and establi...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2016-03, Vol.44 (3), p.463-475
Main Author: Gordon, Siamon
Format: Article
Language:English
Subjects:
Adaptive Immunity
Animals
Autophagy
Biology
Bone marrow
Cytokines
Homeostasis
Humans
Immunity, Cellular
Immunity, Innate
Immunology
Infections
Inflammation
Inflammation - immunology
Ligands
Metabolic disorders
Metabolites
Neutrophils
Phagocytes - immunology
Phagocytosis - immunology
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Summary:It has been a century since the death of Élie Metchnikoff, who championed the role of phagocytosis in cellular immunity. Whereas others had observed the uptake of particles by cells from simple to complex organisms, he grasped its significance in the host response to injury and infection and established a firm basis for our understanding of inflammation and tissue homeostasis. The past century has brought improved tools of cellular and molecular biology to the study of phagocytosis and its contribution to physiological and pathological processes, including receptor function in innate and acquired immunity. In this review, I assess our present knowledge and consider opportunities for future research and therapeutic targeting. Phagocytosis is a cellular process by which specialized leukocytes remove the corpses of dying cells and defend the body against infectious microbes. Siamon Gordon revisits this biological process and places it in the perspective of the phagocyte within its environment.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2016.02.026