Topical spraying of cefazolin and gentamicin reduces deep sternal wound infections after heart surgery: a multicenter, large volume, retrospective study

Objective The use of topical antimicrobials applied to the sternum during cardiac procedures in combination with intravenous agents to prevent mediastinitis has been reported to yield good results. The objective of this study is to provide optimal method of topical antimicrobials for the prevention...

Full description

Saved in:
Bibliographic Details
Published in:General thoracic and cardiovascular surgery 2016-04, Vol.64 (4), p.197-202
Main Authors: Osawa, Hiroshi, Yoshii, Shinpei, Abraham, Samuel J. K., Okamoto, Yuki, Hosaka, Shigeru, Fukuda, Shoji, Tsuchiya, Koji, Nakajima, Masato, Honda, Yoshihiro, Takizawa, Kouki
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Aged
Anti-Bacterial Agents - administration & dosage
Antibiotics
Antimicrobial agents
Cardiac Surgery
Cardiac Surgical Procedures - adverse effects
Cardiology
Cefazolin - administration & dosage
Confidence intervals
Coronary vessels
Diabetes
Disease control
Drug Combinations
Female
Gentamicins - administration & dosage
Heart surgery
Hemodialysis
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Prevention
Retrospective Studies
Risk Factors
Sternum - surgery
Surgeons
Surgical Oncology
Surgical site infections
Surgical Wound Infection - etiology
Surgical Wound Infection - prevention & control
Thoracic Surgery
Veins & arteries
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective The use of topical antimicrobials applied to the sternum during cardiac procedures in combination with intravenous agents to prevent mediastinitis has been reported to yield good results. The objective of this study is to provide optimal method of topical antimicrobials for the prevention of sternal wound infection after cardiac surgery. Methods We retrospectively evaluated the patients undergoing adult cardiac surgery at five institutions between January 1994 and August 2013 for the incidence of deep sternal wound infection (DSWI). The patients were sprayed with a solution of cefazolin and gentamicin into the surgical site several times during surgery. The incidence of DSWI was evaluated. Four major risk factors [diabetes mellitus (DM), emergency operation, dialysis and prolonged operation] were also evaluated for their implications in the outcome with the antimicrobial spraying. Results Totally, 6960 patients were analyzed. The incidence of DSWI was 0.46 % in the spraying group versus 1.7 % in control group ( p  
ISSN:1863-6705
1863-6713
DOI:10.1007/s11748-015-0615-y