Detection of specific antibodies in cord blood, infant and maternal saliva and breast milk to staphylococcal toxins implicated in sudden infant death syndrome (SIDS)

The common bacterial toxins hypothesis of sudden infant death syndrome (SIDS) is that nasopharyngeal bacterial toxins can trigger events leading to death in infants with absent/low levels of antibody that can neutralise the toxins. The aim of this study was to investigate nasopharyngeal carriage of...

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Bibliographic Details
Published in:FEMS immunology and medical microbiology 2004-09, Vol.42 (1), p.94-104
Main Authors: Harrison, Linda M., Morris, James A., Bishop, Lisa A., Lauder, Robert M., Taylor, Christine A.M., Telford, David R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Antibodies
Antibodies, Bacterial - analysis
Antibodies, Bacterial - blood
Antibody Specificity
Babies
Bacterial toxins
Bacterial Toxins - immunology
Birth weight
Blood
Breast
Breast milk
Breastfeeding & lactation
Cord blood
enterotoxins
Enterotoxins - immunology
Enzyme-linked immunosorbent assay
Female
Fetal Blood - immunology
Health risk assessment
Humans
Immune response
Immune system
Immunity
Immunity (passive)
Immunoglobulin A
Immunoglobulin G
Infant
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Infants
Levels
Male
Milk
Milk, Human - immunology
mothers
Mucosal immunity
Saliva
Saliva - immunology
Seasonal variations
Septic shock
SIDS
Staphylococcal enterotoxin C
Staphylococcal enterotoxin F
Staphylococcal Infections - complications
Staphylococcal Infections - immunology
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus - immunology
Sudden Infant Death - etiology
Sudden Infant Death - immunology
Sudden infant death syndrome
Superantigens - immunology
Toxic shock syndrome
toxic shock syndrome toxin
Toxins
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Items that cite this one
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Description
Summary:The common bacterial toxins hypothesis of sudden infant death syndrome (SIDS) is that nasopharyngeal bacterial toxins can trigger events leading to death in infants with absent/low levels of antibody that can neutralise the toxins. The aim of this study was to investigate nasopharyngeal carriage of Staphylococcus aureus and determine levels of immunity in the first year of life to toxic shock syndrome toxin (TSST-1) and staphylococcal enterotoxin C (SEC). Both toxins have been implicated in SIDS cases. Seventy-three mothers and their infants (39 males and 34 females) were enrolled onto the study. The infants had birth dates spread evenly throughout the year. In infants, S. aureus carriage decreased significantly with age ( P
ISSN:0928-8244
1574-695X
2049-632X
DOI:10.1016/j.femsim.2004.06.010