Low levels of vitamin D poorly responsive to daylight exposure in patients with therapy-resistant schizophrenia

Background: Low vitamin D levels are associated with schizophrenia, but the possible association between vitamin D levels and illness severity or duration of exposure to daylight has barely been investigated. Aims: To compare vitamin D levels in therapy-refractory severely ill schizophrenia patients...

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Bibliographic Details
Published in:Nordic journal of psychiatry 2016-05, Vol.70 (4), p.262-266
Main Authors: Bogers, Jan P. A. M., Bostoen, Tijmen, Broekman, Theo G.
Format: Article
Language:English
Subjects:
Adult
Aged
Calcidiol
daylight exposure
Female
Humans
Male
Middle Aged
outdoor time
schizophrenia
Schizophrenia - blood
Schizophrenia - complications
Seasons
Sunlight
therapy resistant
vitamin D
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - therapy
Young Adult
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Summary:Background: Low vitamin D levels are associated with schizophrenia, but the possible association between vitamin D levels and illness severity or duration of exposure to daylight has barely been investigated. Aims: To compare vitamin D levels in therapy-refractory severely ill schizophrenia patients and members of staff. To investigate the influence of daylight exposure on vitamin D levels in patients. Methods: Vitamin D was measured in patients with therapy-resistant schizophrenia in April, after the winter, and in patients and staff members in June, after an exceptionally sunny spring. Vitamin D levels in April and June were compared in patients, and levels in June were compared in patients and staff. The influence of daylight was taken into account by comparing the time patients spent outdoors during the day with the recommended minimum time for adequate vitamin D synthesis, and by comparing time spent outdoors in patients and staff. Results: Patients had high rates of vitamin D deficiency (79-90%) and lower levels of vitamin D than staff members (p 
ISSN:0803-9488
1502-4725
DOI:10.3109/08039488.2015.1086023