Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: a meta-analysis

Background Vasculogenic mimicry (VM) is the formation of vascular channels by tumor cells or tumor cell-derived, trans-differentiated cells in highly aggressive, solid tumors. However, the disease features and prognostic value of VM for overall survival of cancer patients remain controversial. Metho...

Full description

Saved in:
Bibliographic Details
Published in:Angiogenesis (London) 2016-04, Vol.19 (2), p.191-200
Main Authors: Yang, J. P., Liao, Y. D., Mai, D. M., Xie, P., Qiang, Y. Y., Zheng, L. S., Wang, M. Y., Mei, Y., Meng, D. F., Xu, L., Cao, L., Yang, Q., Yang, X. X., Wang, W. B., Peng, L. X., Huang, B. J., Qian, C. N.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cardiology
Cell Biology
Genetic Heterogeneity
Humans
Neoplasms - blood supply
Neoplasms - diagnosis
Neovascularization, Pathologic - pathology
Oncology
Ophthalmology
Original Paper
Prognosis
Publication Bias
Survival Analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Vasculogenic mimicry (VM) is the formation of vascular channels by tumor cells or tumor cell-derived, trans-differentiated cells in highly aggressive, solid tumors. However, the disease features and prognostic value of VM for overall survival of cancer patients remain controversial. Method To systematically investigate the roles of VM in cancer progression and its prognostic values, we performed a meta-analysis based on 36 studies (33 eligible articles) including 3609 patients. The pooled hazard ratios (HRs) with 95 % confidence intervals (95 % CIs) were used to assess the relationship between VM and overall survival in cancer patients. Results Vasculogenic mimicry was significantly associated with cancer differentiation, lymph node metastasis, distant metastasis, and TNM stage. The prognostic value of VM was significant in overall survival (HR 2.16; 95 % CI 1.98–2.38; P  
ISSN:0969-6970
1573-7209
DOI:10.1007/s10456-016-9500-2