Loss of asthma control and activation of coagulation and fibrinolysis

Summary Background Epidemiologic studies have shown that patients with severe asthma have increased risk of pulmonary embolism, in particular patients with frequent asthma exacerbations. Therefore, we hypothesized that asthma exacerbations are associated with increased haemostatic activity. Objectiv...

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Bibliographic Details
Published in:Clinical and experimental allergy 2016-03, Vol.46 (3), p.422-427
Main Authors: Sneeboer, M. M. S., Fens, N., van de Pol, M. A., Majoor, C. J., Meijers, J. C.M., Kamphuisen, P. W., Lutter, R., Sterk, P. J., Bel, E. H.D.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anti-Asthmatic Agents - administration & dosage
Anti-Asthmatic Agents - therapeutic use
asthma
Asthma - blood
Asthma - diagnosis
Asthma - drug therapy
Asthma - physiopathology
Biomarkers
Blood Coagulation
coagulation
Disease Progression
Female
Fibrinolysis
Forced Expiratory Volume
haemostasis
Humans
Leukocyte Count
loss of control
Male
Nitric Oxide - metabolism
Risk Factors
Young Adult
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Summary:Summary Background Epidemiologic studies have shown that patients with severe asthma have increased risk of pulmonary embolism, in particular patients with frequent asthma exacerbations. Therefore, we hypothesized that asthma exacerbations are associated with increased haemostatic activity. Objective To investigate whether induced loss of asthma control is associated with changes in coagulation and fibrinolytic parameters in peripheral blood. Methods We performed a prospective, inhaled steroid withdrawal study in 23 patients with moderate to moderately severe asthma, consisting of a baseline visit and a visit after loss of asthma control. During the visits, we measured asthma control questionnaire (ACQ), atopy, lung function, inflammatory markers (eosinophils and neutrophils), and haemostatic parameters in plasma. Results Complete cessation of inhaled corticosteroids led to a loss of asthma control in 22 of 23 patients. We found increased asthma symptoms (ACQ 0.9 vs. 2.9, P 
ISSN:0954-7894
1365-2222
DOI:10.1111/cea.12667