Minor hallucinations occur in drug-naive Parkinson's disease patients, even from the premotor phase

Objectives The description of minor hallucinatory phenomena (presence, passage hallucinations) has widened the spectrum of psychosis in Parkinson's disease (PD). Minor hallucinatory phenomena seem to antedate the development of more severe hallucinations. Early detection of minor hallucinations...

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Bibliographic Details
Published in:Movement disorders 2016-01, Vol.31 (1), p.45-52
Main Authors: Pagonabarraga, Javier, Martinez-Horta, Saul, Fernández de Bobadilla, Ramón, Pérez, Jesús, Ribosa-Nogué, Roser, Marín, Juan, Pascual-Sedano, Berta, García, Carmen, Gironell, Alexandre, Kulisevsky, Jaime
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
drug-naive
early untreated
Female
hallucinations
Hallucinations - etiology
Humans
Longitudinal Studies
Male
Middle Aged
Movement disorders
Parkinson Disease - complications
Parkinson's disease
premotor
Prospective Studies
Psychiatric Status Rating Scales
REM sleep behavior disorder
Statistics, Nonparametric
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Summary:Objectives The description of minor hallucinatory phenomena (presence, passage hallucinations) has widened the spectrum of psychosis in Parkinson's disease (PD). Minor hallucinatory phenomena seem to antedate the development of more severe hallucinations. Early detection of minor hallucinations may be useful for screening patients with more severe endophenotypes. Motivated by the observation of “de novo,” drug‐naive PD patients reporting minor hallucinations, we aimed to prospectively identify “de novo” untreated PD patients experiencing hallucinatory phenomena, and to compare their clinico‐demographic characteristics with those of untreated PD patients without hallucinations and healthy controls. Methods Screening and description of psychosis was assessed by the Movement Disorders Society Unified Parkinson's Disease Rating Scale—Part I and a structured interview covering all types of psychotic phenomena reported in PD. Clinical, neuropsychological, and demographic data of PD patients with and without psychotic phenomena were compared with those of age‐ and education‐matched healthy controls. Results Fifty drug‐naive, “de novo” PD patients and 100 controls were prospectively included. Minor hallucinations were experienced in 42% (21 of 50) PD patients and 5% controls (P 
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.26432