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Minor hallucinations occur in drug-naive Parkinson's disease patients, even from the premotor phase
Objectives The description of minor hallucinatory phenomena (presence, passage hallucinations) has widened the spectrum of psychosis in Parkinson's disease (PD). Minor hallucinatory phenomena seem to antedate the development of more severe hallucinations. Early detection of minor hallucinations...
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| Published in: | Movement disorders 2016-01, Vol.31 (1), p.45-52 |
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| container_end_page | 52 |
| container_issue | 1 |
| container_start_page | 45 |
| container_title | Movement disorders |
| container_volume | 31 |
| creator | Pagonabarraga, Javier Martinez-Horta, Saul Fernández de Bobadilla, Ramón Pérez, Jesús Ribosa-Nogué, Roser Marín, Juan Pascual-Sedano, Berta García, Carmen Gironell, Alexandre Kulisevsky, Jaime |
| description | Objectives
The description of minor hallucinatory phenomena (presence, passage hallucinations) has widened the spectrum of psychosis in Parkinson's disease (PD). Minor hallucinatory phenomena seem to antedate the development of more severe hallucinations. Early detection of minor hallucinations may be useful for screening patients with more severe endophenotypes. Motivated by the observation of “de novo,” drug‐naive PD patients reporting minor hallucinations, we aimed to prospectively identify “de novo” untreated PD patients experiencing hallucinatory phenomena, and to compare their clinico‐demographic characteristics with those of untreated PD patients without hallucinations and healthy controls.
Methods
Screening and description of psychosis was assessed by the Movement Disorders Society Unified Parkinson's Disease Rating Scale—Part I and a structured interview covering all types of psychotic phenomena reported in PD. Clinical, neuropsychological, and demographic data of PD patients with and without psychotic phenomena were compared with those of age‐ and education‐matched healthy controls.
Results
Fifty drug‐naive, “de novo” PD patients and 100 controls were prospectively included. Minor hallucinations were experienced in 42% (21 of 50) PD patients and 5% controls (P |
| doi_str_mv | 10.1002/mds.26432 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1776658249</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3928843021</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5602-96b43177ad0ac6bb7ef91baea074a63b6b15006e637a08b059ac4141cd4e866a3</originalsourceid><addsrcrecordid>eNqN0U1rFTEUBuAgFnutLvwDEnChQqc9mXxMZlmq3gqtCq3oLmQy53pTZ5JrMlPtvzf2tl0IgqvA4TkvnLyEPGNwwADqw7HPB7USvH5AFkxyVulaNg_JArSWFWda7pLHOV8CMCaZekR2CwZdt2xB3JkPMdG1HYbZ-WAnH0Om0bk5UR9on-ZvVbD-Cuknm777kGN4mWnvM9qMdFM8hinvU7zCQFcpjnRal3nCMU4ld7Mu7AnZWdkh49Pbd498fvf24vikOv24fH98dFo5qaCuWtUJzprG9mCd6roGVy3rLFpohFW8Ux2TAAoVbyzoDmRrnWCCuV6gVsryPfJqm7tJ8ceMeTKjzw6HwQaMczYlWympa9H-B1XQ8roFVeiLv-hlnFMohxQlyw-DEKKo11vlUsw54cpskh9tujYMzJ-STCnJ3JRU7PPbxLkbsb-Xd60UcLgFP_2A1_9OMmdvzu8iq-2GzxP-ut8olRnV8EaaLx-WRl-cL9VXqQ3nvwHjKqm8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1758850444</pqid></control><display><type>article</type><title>Minor hallucinations occur in drug-naive Parkinson's disease patients, even from the premotor phase</title><source>Wiley</source><creator>Pagonabarraga, Javier ; Martinez-Horta, Saul ; Fernández de Bobadilla, Ramón ; Pérez, Jesús ; Ribosa-Nogué, Roser ; Marín, Juan ; Pascual-Sedano, Berta ; García, Carmen ; Gironell, Alexandre ; Kulisevsky, Jaime</creator><creatorcontrib>Pagonabarraga, Javier ; Martinez-Horta, Saul ; Fernández de Bobadilla, Ramón ; Pérez, Jesús ; Ribosa-Nogué, Roser ; Marín, Juan ; Pascual-Sedano, Berta ; García, Carmen ; Gironell, Alexandre ; Kulisevsky, Jaime</creatorcontrib><description>Objectives
The description of minor hallucinatory phenomena (presence, passage hallucinations) has widened the spectrum of psychosis in Parkinson's disease (PD). Minor hallucinatory phenomena seem to antedate the development of more severe hallucinations. Early detection of minor hallucinations may be useful for screening patients with more severe endophenotypes. Motivated by the observation of “de novo,” drug‐naive PD patients reporting minor hallucinations, we aimed to prospectively identify “de novo” untreated PD patients experiencing hallucinatory phenomena, and to compare their clinico‐demographic characteristics with those of untreated PD patients without hallucinations and healthy controls.
Methods
Screening and description of psychosis was assessed by the Movement Disorders Society Unified Parkinson's Disease Rating Scale—Part I and a structured interview covering all types of psychotic phenomena reported in PD. Clinical, neuropsychological, and demographic data of PD patients with and without psychotic phenomena were compared with those of age‐ and education‐matched healthy controls.
Results
Fifty drug‐naive, “de novo” PD patients and 100 controls were prospectively included. Minor hallucinations were experienced in 42% (21 of 50) PD patients and 5% controls (P < 0.0001). Coexistence of passage and presence hallucinations was the most common finding. Unexpectedly, 33.3% of patients with minor hallucinations manifested these as a pre‐motor symptom, starting 7 months to 8 years before first parkinsonian motor symptoms. The presence of minor hallucinations was significantly associated with presence of rapid eye movement sleep behavior disorder.
Conclusions
In this first study to prospectively analyze the frequency of minor hallucinatory phenomena in incident, untreated PD patients, hallucinations appeared as a frequent early non‐motor symptom that may even predate the onset of parkinsonism. © 2015 International Parkinson and Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.26432</identifier><identifier>PMID: 26408291</identifier><identifier>CODEN: MOVDEA</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; drug-naive ; early untreated ; Female ; hallucinations ; Hallucinations - etiology ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Movement disorders ; Parkinson Disease - complications ; Parkinson's disease ; premotor ; Prospective Studies ; Psychiatric Status Rating Scales ; REM sleep behavior disorder ; Statistics, Nonparametric</subject><ispartof>Movement disorders, 2016-01, Vol.31 (1), p.45-52</ispartof><rights>2015 International Parkinson and Movement Disorder Society</rights><rights>2015 International Parkinson and Movement Disorder Society.</rights><rights>2016 International Parkinson and Movement Disorder Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5602-96b43177ad0ac6bb7ef91baea074a63b6b15006e637a08b059ac4141cd4e866a3</citedby><cites>FETCH-LOGICAL-c5602-96b43177ad0ac6bb7ef91baea074a63b6b15006e637a08b059ac4141cd4e866a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26408291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pagonabarraga, Javier</creatorcontrib><creatorcontrib>Martinez-Horta, Saul</creatorcontrib><creatorcontrib>Fernández de Bobadilla, Ramón</creatorcontrib><creatorcontrib>Pérez, Jesús</creatorcontrib><creatorcontrib>Ribosa-Nogué, Roser</creatorcontrib><creatorcontrib>Marín, Juan</creatorcontrib><creatorcontrib>Pascual-Sedano, Berta</creatorcontrib><creatorcontrib>García, Carmen</creatorcontrib><creatorcontrib>Gironell, Alexandre</creatorcontrib><creatorcontrib>Kulisevsky, Jaime</creatorcontrib><title>Minor hallucinations occur in drug-naive Parkinson's disease patients, even from the premotor phase</title><title>Movement disorders</title><addtitle>Mov Disord</addtitle><description>Objectives
The description of minor hallucinatory phenomena (presence, passage hallucinations) has widened the spectrum of psychosis in Parkinson's disease (PD). Minor hallucinatory phenomena seem to antedate the development of more severe hallucinations. Early detection of minor hallucinations may be useful for screening patients with more severe endophenotypes. Motivated by the observation of “de novo,” drug‐naive PD patients reporting minor hallucinations, we aimed to prospectively identify “de novo” untreated PD patients experiencing hallucinatory phenomena, and to compare their clinico‐demographic characteristics with those of untreated PD patients without hallucinations and healthy controls.
Methods
Screening and description of psychosis was assessed by the Movement Disorders Society Unified Parkinson's Disease Rating Scale—Part I and a structured interview covering all types of psychotic phenomena reported in PD. Clinical, neuropsychological, and demographic data of PD patients with and without psychotic phenomena were compared with those of age‐ and education‐matched healthy controls.
Results
Fifty drug‐naive, “de novo” PD patients and 100 controls were prospectively included. Minor hallucinations were experienced in 42% (21 of 50) PD patients and 5% controls (P < 0.0001). Coexistence of passage and presence hallucinations was the most common finding. Unexpectedly, 33.3% of patients with minor hallucinations manifested these as a pre‐motor symptom, starting 7 months to 8 years before first parkinsonian motor symptoms. The presence of minor hallucinations was significantly associated with presence of rapid eye movement sleep behavior disorder.
Conclusions
In this first study to prospectively analyze the frequency of minor hallucinatory phenomena in incident, untreated PD patients, hallucinations appeared as a frequent early non‐motor symptom that may even predate the onset of parkinsonism. © 2015 International Parkinson and Movement Disorder Society</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>drug-naive</subject><subject>early untreated</subject><subject>Female</subject><subject>hallucinations</subject><subject>Hallucinations - etiology</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson's disease</subject><subject>premotor</subject><subject>Prospective Studies</subject><subject>Psychiatric Status Rating Scales</subject><subject>REM sleep behavior disorder</subject><subject>Statistics, Nonparametric</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqN0U1rFTEUBuAgFnutLvwDEnChQqc9mXxMZlmq3gqtCq3oLmQy53pTZ5JrMlPtvzf2tl0IgqvA4TkvnLyEPGNwwADqw7HPB7USvH5AFkxyVulaNg_JArSWFWda7pLHOV8CMCaZekR2CwZdt2xB3JkPMdG1HYbZ-WAnH0Om0bk5UR9on-ZvVbD-Cuknm777kGN4mWnvM9qMdFM8hinvU7zCQFcpjnRal3nCMU4ld7Mu7AnZWdkh49Pbd498fvf24vikOv24fH98dFo5qaCuWtUJzprG9mCd6roGVy3rLFpohFW8Ux2TAAoVbyzoDmRrnWCCuV6gVsryPfJqm7tJ8ceMeTKjzw6HwQaMczYlWympa9H-B1XQ8roFVeiLv-hlnFMohxQlyw-DEKKo11vlUsw54cpskh9tujYMzJ-STCnJ3JRU7PPbxLkbsb-Xd60UcLgFP_2A1_9OMmdvzu8iq-2GzxP-ut8olRnV8EaaLx-WRl-cL9VXqQ3nvwHjKqm8</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Pagonabarraga, Javier</creator><creator>Martinez-Horta, Saul</creator><creator>Fernández de Bobadilla, Ramón</creator><creator>Pérez, Jesús</creator><creator>Ribosa-Nogué, Roser</creator><creator>Marín, Juan</creator><creator>Pascual-Sedano, Berta</creator><creator>García, Carmen</creator><creator>Gironell, Alexandre</creator><creator>Kulisevsky, Jaime</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201601</creationdate><title>Minor hallucinations occur in drug-naive Parkinson's disease patients, even from the premotor phase</title><author>Pagonabarraga, Javier ; Martinez-Horta, Saul ; Fernández de Bobadilla, Ramón ; Pérez, Jesús ; Ribosa-Nogué, Roser ; Marín, Juan ; Pascual-Sedano, Berta ; García, Carmen ; Gironell, Alexandre ; Kulisevsky, Jaime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5602-96b43177ad0ac6bb7ef91baea074a63b6b15006e637a08b059ac4141cd4e866a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>drug-naive</topic><topic>early untreated</topic><topic>Female</topic><topic>hallucinations</topic><topic>Hallucinations - etiology</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Movement disorders</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson's disease</topic><topic>premotor</topic><topic>Prospective Studies</topic><topic>Psychiatric Status Rating Scales</topic><topic>REM sleep behavior disorder</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pagonabarraga, Javier</creatorcontrib><creatorcontrib>Martinez-Horta, Saul</creatorcontrib><creatorcontrib>Fernández de Bobadilla, Ramón</creatorcontrib><creatorcontrib>Pérez, Jesús</creatorcontrib><creatorcontrib>Ribosa-Nogué, Roser</creatorcontrib><creatorcontrib>Marín, Juan</creatorcontrib><creatorcontrib>Pascual-Sedano, Berta</creatorcontrib><creatorcontrib>García, Carmen</creatorcontrib><creatorcontrib>Gironell, Alexandre</creatorcontrib><creatorcontrib>Kulisevsky, Jaime</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pagonabarraga, Javier</au><au>Martinez-Horta, Saul</au><au>Fernández de Bobadilla, Ramón</au><au>Pérez, Jesús</au><au>Ribosa-Nogué, Roser</au><au>Marín, Juan</au><au>Pascual-Sedano, Berta</au><au>García, Carmen</au><au>Gironell, Alexandre</au><au>Kulisevsky, Jaime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Minor hallucinations occur in drug-naive Parkinson's disease patients, even from the premotor phase</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov Disord</addtitle><date>2016-01</date><risdate>2016</risdate><volume>31</volume><issue>1</issue><spage>45</spage><epage>52</epage><pages>45-52</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><coden>MOVDEA</coden><abstract>Objectives
The description of minor hallucinatory phenomena (presence, passage hallucinations) has widened the spectrum of psychosis in Parkinson's disease (PD). Minor hallucinatory phenomena seem to antedate the development of more severe hallucinations. Early detection of minor hallucinations may be useful for screening patients with more severe endophenotypes. Motivated by the observation of “de novo,” drug‐naive PD patients reporting minor hallucinations, we aimed to prospectively identify “de novo” untreated PD patients experiencing hallucinatory phenomena, and to compare their clinico‐demographic characteristics with those of untreated PD patients without hallucinations and healthy controls.
Methods
Screening and description of psychosis was assessed by the Movement Disorders Society Unified Parkinson's Disease Rating Scale—Part I and a structured interview covering all types of psychotic phenomena reported in PD. Clinical, neuropsychological, and demographic data of PD patients with and without psychotic phenomena were compared with those of age‐ and education‐matched healthy controls.
Results
Fifty drug‐naive, “de novo” PD patients and 100 controls were prospectively included. Minor hallucinations were experienced in 42% (21 of 50) PD patients and 5% controls (P < 0.0001). Coexistence of passage and presence hallucinations was the most common finding. Unexpectedly, 33.3% of patients with minor hallucinations manifested these as a pre‐motor symptom, starting 7 months to 8 years before first parkinsonian motor symptoms. The presence of minor hallucinations was significantly associated with presence of rapid eye movement sleep behavior disorder.
Conclusions
In this first study to prospectively analyze the frequency of minor hallucinatory phenomena in incident, untreated PD patients, hallucinations appeared as a frequent early non‐motor symptom that may even predate the onset of parkinsonism. © 2015 International Parkinson and Movement Disorder Society</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26408291</pmid><doi>10.1002/mds.26432</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0885-3185 |
| ispartof | Movement disorders, 2016-01, Vol.31 (1), p.45-52 |
| issn | 0885-3185 1531-8257 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1776658249 |
| source | Wiley |
| subjects | Adult Aged Aged, 80 and over drug-naive early untreated Female hallucinations Hallucinations - etiology Humans Longitudinal Studies Male Middle Aged Movement disorders Parkinson Disease - complications Parkinson's disease premotor Prospective Studies Psychiatric Status Rating Scales REM sleep behavior disorder Statistics, Nonparametric |
| title | Minor hallucinations occur in drug-naive Parkinson's disease patients, even from the premotor phase |
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