Using admixture analysis to examine birth-cohort effects on age at onset of bipolar disorder

• Published in: Acta psychiatrica Scandinavica 2016-03, Vol.133 (3), p.205-213
• Main Authors: Golmard, J.-L., Scott, J., Etain, B., Preisig, M., Aubry, J.-M., Henry, C., Jamain, S., Azorin, J.-M., Leboyer, M., Bellivier, F.
• Format: Article
• Language: English
• Subjects: Adult; age at onset; Age of Onset; Bipolar disorder; Bipolar Disorder - diagnosis; Bipolar Disorder - epidemiology; bipolar I disorder; birth-cohort effect; Cohort Effect; Female; France - epidemiology; Humans; Male; Middle Aged; Prospective Studies; Psychiatry; Psychopathology; Risk Factors
• ISSN: 0001-690X; 1600-0447
• DOI: 10.1111/acps.12478

Objective It is suggested that age at onset (AAO) of bipolar I disorder (BP‐I) is decreasing. We tested for a birth‐cohort effect on AAO using admixture analysis. Method A clinical sample of 3896 BP‐I cases was analysed using two approaches: (i) in a subsample with untruncated AAO × birth year distribution (n = 1865), we compared the best‐fitting model for the observed AAO in patients born ≤1960 and >1960, (ii) to control for potential confounders, two separate subsamples born ≤1960 and >1960 were matched for age at interview (n = 250), and a further admixture analysis was undertaken. Results The two approaches indicated that the proportion of cases in the early AAO category was significantly greater in cases born >1960; manic onsets were also more frequent in the early onset BP‐I cases born >1960. Conclusion The decrease in AAO of BP‐I in recent birth‐cohorts appears to be associated with an increase in the proportion of cases in the early onset subgroup; not with a decrease in the mean AAO in each putative subgroup. This could indicate temporal changes in exposure to risk factors for mania.