A database for tracking toxicogenomic samples and procedures

Reproductive toxicogenomic studies generate large amounts of toxicological and genomic data. On the toxicology side, a substantial quantity of data accumulates from conventional endpoints such as histology, reproductive physiology and biochemistry. The largest source of genomics data is DNA microarr...

Full description

Saved in:
Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2005, Vol.19 (3), p.411-419
Main Authors: Bao, Wenjun, Schmid, Judith E., Goetz, Amber K., Ren, Hongzu, Dix, David J.
Format: Article
Language:English
Subjects:
Database Management Systems
Databases, Factual
Gene Expression Profiling
Genomics
Genomics - methods
Information Storage and Retrieval
Microarray
Microsoft Access
Oligonucleotide Array Sequence Analysis
Public Health Informatics
Public Sector
Relational database
Toxicology
Toxicology - methods
User-Computer Interface
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Reproductive toxicogenomic studies generate large amounts of toxicological and genomic data. On the toxicology side, a substantial quantity of data accumulates from conventional endpoints such as histology, reproductive physiology and biochemistry. The largest source of genomics data is DNA microarrays, which generate enormous amounts of information in the course of profiling gene expression. Thus, data storage and management become essential and require a more sophisticated system than lab notebooks and electronic spreadsheets. We developed a database for tracking toxicogenomic samples and procedures (TSP 1.0) for our reproductive studies based on the MIAME-Tox guidelines and relational database theory. This database stores the various types of data from both toxicological and genomic assays in a hierarchical fashion. The user-friendly interface provides easy procedures for researchers to add, edit, save, delete, and navigate different records. Finally, TSP facilitates exporting microarray data into public databases.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2004.09.005