Priority needs and wisdom strategy for blood transfusion safety in developing low-resource countries

Abstract Objective To evaluate the implementation of alternative safety measures that reduce the risk of transfusion transmissible infections as an affordable measure in low resource countries. Background It is still difficult in developing countries with limited resources to mandate nucleic acid te...

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Bibliographic Details
Published in:Transfusion and apheresis science 2016-02, Vol.54 (1), p.147-149
Main Authors: Abdelrazik, Abeer Mohamed, Ezzat Ahmed, Ghada M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Blood Donors
Blood Transfusion
Developing Countries
Donations
Health Priorities
Health technology assessment
Hematology, Oncology and Palliative Medicine
Humans
Infectious disease testing
Middle Aged
Nucleic acid testing
Nucleic Acids - genetics
Safety
Young Adult
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Summary:Abstract Objective To evaluate the implementation of alternative safety measures that reduce the risk of transfusion transmissible infections as an affordable measure in low resource countries. Background It is still difficult in developing countries with limited resources to mandate nucleic acid testing due to its high cost. Although NAT reduces the window period of infection, the developing countries are still in need of an efficient and effective transfusion programme before implementing the complex high cost NAT. Study Design and Methods Two thousand eight hundred eighty sero-negative first-time and repeat donations from Fayoum University Hospital blood bank were individually analysed by NAT for HIV, HBV and HCV. Only discriminatory-positive NAT were classified comparing the non-remunerated and family replacement donations. Results Significant discriminatory-positive differences were observed for HBV NAT results, 2 remunerated donations compared to 0 non-remunerated sero-negative donations. The discriminatory positive differences were also significant for HCV NAT results, 4 remunerated donations compared to 1 non-remunerated sero-negative donation. No sero-negative, discriminatory-positive NAT HIV case was found. Seven out of 8 discriminatory positive cases were from first time donations. Conclusion In order to ensure blood safety, the recruitment and retention of voluntary, non-remunerated repeat donors should be a major commitment for low resource countries in which NAT implementation is costly and not feasible.
ISSN:1473-0502
1878-1683
DOI:10.1016/j.transci.2015.12.003