Priority needs and wisdom strategy for blood transfusion safety in developing low-resource countries

• Published in: Transfusion and apheresis science 2016-02, Vol.54 (1), p.147-149
• Main Authors: Abdelrazik, Abeer Mohamed, Ezzat Ahmed, Ghada M
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Blood Donors; Blood Transfusion; Developing Countries; Donations; Health Priorities; Health technology assessment; Hematology, Oncology and Palliative Medicine; Humans; Infectious disease testing; Middle Aged; Nucleic acid testing; Nucleic Acids - genetics; Safety; Young Adult
• ISSN: 1473-0502; 1878-1683
• DOI: 10.1016/j.transci.2015.12.003

Abstract Objective To evaluate the implementation of alternative safety measures that reduce the risk of transfusion transmissible infections as an affordable measure in low resource countries. Background It is still difficult in developing countries with limited resources to mandate nucleic acid testing due to its high cost. Although NAT reduces the window period of infection, the developing countries are still in need of an efficient and effective transfusion programme before implementing the complex high cost NAT. Study Design and Methods Two thousand eight hundred eighty sero-negative first-time and repeat donations from Fayoum University Hospital blood bank were individually analysed by NAT for HIV, HBV and HCV. Only discriminatory-positive NAT were classified comparing the non-remunerated and family replacement donations. Results Significant discriminatory-positive differences were observed for HBV NAT results, 2 remunerated donations compared to 0 non-remunerated sero-negative donations. The discriminatory positive differences were also significant for HCV NAT results, 4 remunerated donations compared to 1 non-remunerated sero-negative donation. No sero-negative, discriminatory-positive NAT HIV case was found. Seven out of 8 discriminatory positive cases were from first time donations. Conclusion In order to ensure blood safety, the recruitment and retention of voluntary, non-remunerated repeat donors should be a major commitment for low resource countries in which NAT implementation is costly and not feasible.