Pre-awakening diastolic hypotension in treated hypertensive patients: prevalence and predictors

In the pre-awakening hours, diastolic blood pressure (DBP) is normally at its lowest, and diastolic hypotension is a risk factor for cardiac ischemia. We investigated pre-awakening DBP values and its predictors in treated hypertensive patients who underwent ambulatory blood pressure monitoring. The...

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Published in:Journal of human hypertension 2016-05, Vol.30 (5), p.322-327
Main Authors: Zheng, K H, Serné, E H, Kooter, A J, Smulders, Y M
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692/499
692/699/75/243
692/700
Aged
Antihypertensives
Blood pressure
Circadian Rhythm
Development and progression
Diabetes mellitus
Diastole
Diastole (Cardiac cycle)
Epidemiology
Female
Health Administration
Humans
Hypertension
Hypertension - physiopathology
Hypotension
Hypotension - epidemiology
Ischemia
Male
Measurement
Medicine
Medicine & Public Health
Middle Aged
Netherlands - epidemiology
original-article
Prevalence
Public Health
Regulation
Retrospective Studies
Risk factors
Sleep - physiology
Vascular diseases
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description In the pre-awakening hours, diastolic blood pressure (DBP) is normally at its lowest, and diastolic hypotension is a risk factor for cardiac ischemia. We investigated pre-awakening DBP values and its predictors in treated hypertensive patients who underwent ambulatory blood pressure monitoring. The pre-awakening period was defined as the 3-h period ending 1 h before awakening (most frequently 03:00–06:00). In 269 included subjects, office DBP was 86.4±12.0 mm Hg, 24-h DBP was 78.6±9.6 mm Hg, mean pre-awakening DBP was 70.3±10.9 mm Hg, and trough pre-awakening DBP was 62.5±11.2 mm Hg. Half of the patients (51%) had a mean pre-awakening DBP
doi_str_mv 10.1038/jhh.2015.80
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We investigated pre-awakening DBP values and its predictors in treated hypertensive patients who underwent ambulatory blood pressure monitoring. The pre-awakening period was defined as the 3-h period ending 1 h before awakening (most frequently 03:00–06:00). In 269 included subjects, office DBP was 86.4±12.0 mm Hg, 24-h DBP was 78.6±9.6 mm Hg, mean pre-awakening DBP was 70.3±10.9 mm Hg, and trough pre-awakening DBP was 62.5±11.2 mm Hg. Half of the patients (51%) had a mean pre-awakening DBP <70 mm Hg, and 14% had <60 mm Hg. Trough pre-awakening DBP <60 mm Hg was seen in 36% and <50 mm Hg in 12% of patients. Office DBP was the most important predictor of mean and trough pre-awakening DBP (both beta=0.4; P <0.001), and of pre-awakening DBP <70 mm Hg and <60 mm Hg (both P ⩽0.001). Diabetes mellitus was associated with a lower trough pre-awakening DBP (beta=−3.2; P =0.02). 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subjects 692/499
692/699/75/243
692/700
Aged
Antihypertensives
Blood pressure
Circadian Rhythm
Development and progression
Diabetes mellitus
Diastole
Diastole (Cardiac cycle)
Epidemiology
Female
Health Administration
Humans
Hypertension
Hypertension - physiopathology
Hypotension
Hypotension - epidemiology
Ischemia
Male
Measurement
Medicine
Medicine & Public Health
Middle Aged
Netherlands - epidemiology
original-article
Prevalence
Public Health
Regulation
Retrospective Studies
Risk factors
Sleep - physiology
Vascular diseases
title Pre-awakening diastolic hypotension in treated hypertensive patients: prevalence and predictors
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