Spontaneous Retinopathy in HLA-A29 Transgenic Mice

Humans who have inherited the class I major histocompatibility allele HLA-A29 have a markedly increased relative risk of developing the eye disease termed birdshot chorioretinopathy. This disease affecting adults is characterized by symmetrically scattered, small, cream-colored spots in the fundus a...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2001-02, Vol.98 (5), p.2572-2576
Main Authors: Szpak, Yann, Vieville, Jean-Claude, Tabary, Thierry, Naud, Marie-Christine, Chopin, Martine, Edelson, Catherine, Jacques H. M. Cohen, Dausset, Jean, de Kozak, Yvonne, Pla, Marika
Format: Article
Language:English
Subjects:
Animals
Biological Sciences
Disease
Eye diseases
Eyes
Eyes & eyesight
Flow Cytometry
histocompatibility antigen HLA
HLA antigens
HLA-A Antigens - genetics
HLA-A Antigens - physiology
HLA-A29 gene
Immunology
Mice
Mice, Inbred BALB C
Mice, Transgenic
Molecules
Pathology
Retina
Retinal diseases
Retinal Diseases - immunology
Retinal Diseases - pathology
Rodents
Transgenes
Transgenic animals
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Summary:Humans who have inherited the class I major histocompatibility allele HLA-A29 have a markedly increased relative risk of developing the eye disease termed birdshot chorioretinopathy. This disease affecting adults is characterized by symmetrically scattered, small, cream-colored spots in the fundus associated with retinal vasculopathy and inflammatory signs causing damage to the ocular structures, leading regularly to visual loss. To investigate the role of HLA-A29 in this disease, we introduced the HLA-A29 gene into mice. Aging HLA-A29 transgenic mice spontaneously developed retinopathy, showing a striking resemblance to the HLA-A29-associated chorioretinopathy. These results strongly suggest that HLA-A29 is involved in the pathogenesis of this disease. Elucidation of the role of HLA-A29 should be assisted by this transgenic model.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.051595998