Effect of Food Load on Activities of Enzymes of the Main Metabolic Pathways in Blood Lymphocytes in Girls with Different Anthropometric Parameters

Changes in enzyme activities reflecting functioning of the basic metabolic pathways in cells (Krebs cycle, glycolysis, pentose phosphate pathway) were evaluated in blood lymphocytes of girls of different somatotypes with different body composition under conditions of food load. A common regularity w...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-07, Vol.159 (3), p.309-313
Main Authors: Fefelova, V. V., Fefelova, Yu. A., Kazakova, T. V., Koloskova, T. P., Sergeeva, E. Yu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anthropometry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Child
Citric Acid Cycle - physiology
Dextrose
Enzymes
Fasting - blood
Female
Food
Glucose
Glucose metabolism
Glucosephosphate Dehydrogenase - blood
Glycolysis - physiology
Healthy Volunteers
Humans
Internal Medicine
Laboratory Medicine
Lymphocytes
Lymphocytes - metabolism
Metabolic Networks and Pathways - physiology
Oxidation-Reduction
Pathology
Pentose Phosphate Pathway - physiology
Phosphates
Physiological aspects
Succinate Dehydrogenase - blood
Young Adult
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Summary:Changes in enzyme activities reflecting functioning of the basic metabolic pathways in cells (Krebs cycle, glycolysis, pentose phosphate pathway) were evaluated in blood lymphocytes of girls of different somatotypes with different body composition under conditions of food load. A common regularity was found: a decrease in succinate dehydrogenase activity after meal in girls of all somatotypes. Specific features of individual somatotypes were also revealed. Only girls of athletic somatotype showed increased lactate dehydrogenase level after food load. Activity of glucose-6-phosphate dehydrogenase increased (more than twice) after food load only in girls of euryplastic somatotype. This somatotype is characterized by maximum values of fat andother components of the body. Glucose-6-phosphate dehydrogenase is the first enzyme of the pentose phosphate pathway; activation of this pathway accompanies enhancement of synthetic processes, including lipid synthesis. This can contribute to accumulation of the fat component (and other components) due to redistribution of substrate flows between metabolic pathways.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2949-y