The diagnostic performance of cardiac magnetic resonance in detection of myocardial involvement in AL amyloidosis

• Published in: Clinical physiology and functional imaging 2016-05, Vol.36 (3), p.218-224
• Main Authors: Fikrle, Michal, Palecek, Tomas, Masek, Martin, Kuchynka, Petr, Straub, Jan, Spicka, Ivan, Rysava, Romana, Linhart, Ales
• Format: Article
• Language: English
• Subjects: Aged; AL amyloidosis; Amyloidosis - complications; Amyloidosis - diagnostic imaging; cardiac magnetic resonance; Cardiomyopathies - complications; Cardiomyopathies - diagnostic imaging; cardiomyopathy; Echocardiography; Female; Humans; late gadolinium enhancement; Magnetic Resonance Imaging, Cine - methods; Male; Reproducibility of Results; Sensitivity and Specificity; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - etiology
• ISSN: 1475-0961; 1475-097X
• DOI: 10.1111/cpf.12216

Summary Background The non‐invasive assessment of amyloid heart disease may be challenging. Cardiac magnetic resonance (CMR) represents a method of choice for assessment of left ventricular (LV) morphology and function, and it also provides a unique possibility to evaluate the presence of amyloid deposition by the late gadolinium enhancement (LGE) technique. However, so far, published studies have not been consistent in terms of described LGE patterns associated with amyloid cardiomyopathy. Aims To compare echocardiographic and CMR assessment of LV morphology and function and to evaluate the presence and pattern of LGE in a population of patients with AL amyloid cardiomyopathy. Methods Twenty‐two consecutive patients with newly diagnosed AL amyloid cardiomyopathy and without contraindications to CMR were comprehensively examined by echocardiography and CMR. Results Echocardiography and CMR did not differ in the evaluation of interventricular septal thickness, LV end‐diastolic diameter and ejection fraction. Significant differences were found between echocardiographic and CMR estimates of LV end‐diastolic volume (P