Roles and regulation of the matrix metalloproteinase system in parturition

SUMMARY Significant tissue destruction, repair, and remodeling are involved in parturition, which involves fetal membrane rupture, cervical ripening, and uterine contraction and its subsequent involution. Extracellular matrix degradation and remodeling by proteolytic enzymes, such as matrix metallop...

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Bibliographic Details
Published in:Molecular reproduction and development 2016-04, Vol.83 (4), p.276-286
Main Authors: Geng, Junnan, Huang, Cong, Jiang, Siwen
Format: Article
Language:English
Subjects:
Animals
Extracellular Matrix - enzymology
Female
Humans
Matrix Metalloproteinases - metabolism
Parturition - metabolism
Pregnancy
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Summary:SUMMARY Significant tissue destruction, repair, and remodeling are involved in parturition, which involves fetal membrane rupture, cervical ripening, and uterine contraction and its subsequent involution. Extracellular matrix degradation and remodeling by proteolytic enzymes, such as matrix metalloproteinases (MMPs), are required for the final steps of parturition. MMPs participate in physiological degradation and remodeling through their proteolytic activities on specific substrates, and are balanced by the action of their inhibitors. Disruption to this balance can result in pathological stress that ends with preterm or post‐term birth or pre‐eclampsia. In this review, we examine the roles and regulation of the MMP system in physiological and pathological labor, and propose a model that illustrates the mechanisms by which the MMP system contributes to these processes. Mol. Reprod. Dev. 83: 276–286, 2016. © 2016 Wiley Periodicals, Inc.
ISSN:1040-452X
1098-2795
DOI:10.1002/mrd.22626