Development of a complementary PET/MR dual-modal imaging probe for targeting prostate-specific membrane antigen (PSMA)

We tried to develop a dual-modal PET/MR imaging probe using a straightforward one-pot method by encapsulation with specific amphiphiles. In this study, iron oxide (IO) nanoparticles were encapsulated with three amphiphiles containing PEG, DOTA and the prostate-specific membrane antigen (PSMA)-target...

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Bibliographic Details
Published in:Nanomedicine 2016-05, Vol.12 (4), p.871-879
Main Authors: Moon, Sung-Hyun, Yang, Bo Yeun, Kim, Young Ju, Hong, Mee Kyung, Lee, Yun-Sang, Lee, Dong Soo, Chung, June-Key, Jeong, Jae Min
Format: Article
Language:English
Subjects:
Animals
Antigens, Surface - chemistry
Antigens, Surface - genetics
Antigens, Surface - isolation & purification
Cell Line, Tumor
Encapsulation
Ferric Compounds - administration & dosage
Ferric Compounds - chemistry
Gallium-68
Glutamate Carboxypeptidase II - chemistry
Glutamate Carboxypeptidase II - genetics
Glutamate Carboxypeptidase II - isolation & purification
GUL
Humans
Internal Medicine
Ligands
Magnetic Resonance Imaging
Male
Mice
Multi-modal
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Positron-Emission Tomography
Prostate cancer
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Tomography, X-Ray Computed
Xenograft Model Antitumor Assays
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