The serum levels of Receptor Activator of Nuclear Factor-κB Ligand, bone-specific alkaline phosphatase, osteocalcin and osteoprotegerin do not correlate with the radiographically assessed severity of idiopathic hip and knee osteoarthritis

Determination of the serum levels of Receptor Activator of Nuclear Factor-Κb Ligand, bone-specific alkaline phosphatase, osteocalcin and osteoprotegerin in patients suffering from osteoarthritis of varying severity and healthy controls and correlation of these results with the patients' age and...

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Published in:Clinical biochemistry 2011-02, Vol.44 (2), p.203-207
Main Authors: Kenanidis, Eustathios Ι., Potoupnis, Michael E., Papavasiliou, Kyriakos A., Pellios, Stauros, Sayegh, Fares E., Petsatodis, George E., Karatzas, Nikolaos, Kapetanos, George A.
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - blood
Biological and medical sciences
Bone turnover markers
Bone-specific alkaline phosphatase
Diseases of the osteoarticular system
Hip osteoarthritis
Humans
Knee osteoarthritis
Medical sciences
Miscellaneous. Osteoarticular involvement in other diseases
Osteoarthritis
Osteoarthritis, Knee
Osteocalcin
Osteocalcin - blood
Osteoprotegerin
Osteoprotegerin - blood
RANK Ligand - blood
Receptor Activator of Nuclear Factor-κB Ligand
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Summary:Determination of the serum levels of Receptor Activator of Nuclear Factor-Κb Ligand, bone-specific alkaline phosphatase, osteocalcin and osteoprotegerin in patients suffering from osteoarthritis of varying severity and healthy controls and correlation of these results with the patients' age and the radiographically assessed severity of the disease. Patients suffering from hip ( n = 58) or knee ( n = 117) osteoarthritis and matched controls ( n = 19) were enrolled in this study. Patients underwent physical examination and standard radiographic evaluation before blood sampling. The serum levels of osteoprotegerin were positively correlated with age in all groups, whereas those of osteocalcin in the ‘knee’ group only. Osteoarthritis' severity and location did not have a statistically significant impact on the mean serum level of any marker in both groups. Based on our results, none of the studied markers can serve as a surrogate for radiographic imaging in patients suffering from hip and knee osteoarthritis.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2010.09.029