Outcomes for Management of Lichen Sclerosus Urethral Strictures by 3 Different Techniques

• Published in: Urology (Ridgewood, N.J.) N.J.), 2016-05, Vol.91, p.215-221
• Main Authors: Patel, Chintan K, Buckley, Jill C, Zinman, Leonard N, Vanni, Alex J
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Humans; Lichen Sclerosus et Atrophicus - complications; Male; Middle Aged; Mouth Mucosa - transplantation; Retrospective Studies; Treatment Outcome; Urethra - surgery; Urethral Stricture - etiology; Urethral Stricture - surgery; Urologic Surgical Procedures, Male - methods; Urology; Young Adult
• ISSN: 0090-4295; 1527-9995
• DOI: 10.1016/j.urology.2015.11.057

Objective To evaluate the intermediate-term outcomes from a large, single institution series of patients with lichen sclerosus (LS) who underwent surgical management of their urethral strictures. Materials and Methods We retrospectively reviewed 79 patients who underwent surgical management of their LS urethral strictures from 2003 to 2014, comparing outcomes of patients undergoing a single-stage buccal mucosa graft (BMG) urethroplasty, 2-stage BMG urethroplasty, or perineal urethrostomy (PU). Demographic and surgical outcomes data were collected for all patients. Results Of the 79 patients, the mean follow-up was 32.4 months, mean age was 50.1 years, and the mean body mass index was 35.7, with morbid obesity (body mass index > 35) in 48% of the cohort. The mean stricture length was 9.6 cm (1.5-21 cm), with 62% of patients having a bulbopendulous stricture. Of the 37 patients who were planned for a 2-stage BMG urethroplasty, 9 (24%) patients had stricture recurrence or recurrent LS in the first-stage BMG. Single-stage BMG urethroplasty was performed in 20 patients with a mean stricture length of 9.47 cm (4-21 cm) and a success rate of 75%. Fourteen patients from the cohort received a PU as the primary treatment, with a success rate of 93%. Conclusion Management of LS strictures continues to pose challenges to the reconstructive surgeon due to the high rate of stricture recurrence and often progression. Patients undergoing single-stage or 2-stage reconstruction often require revision and must be carefully observed for recurrent urethral stricture. PU offers the highest degree of success and should be considered for all patients.